Effect of Naoling decoction on iNOS expression in hippocampal CA3 region in rats with synthetic Alzheimer's disease

To observe the effect of Naoling decoction on the expression of iNOS in hippocamal CA3 region in rats with Alzheimer's disease (AD), and to explore the potential mechanism. Forty SD rats were classified into 5 groups: a normal group, a sham-operated group, an AD group, a Naoling decoction group...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban 2010-09, Vol.35 (9), p.910-914
Hauptverfasser:	Zhong, Bingwu, Wang, Zhe, He, Mingda
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - chemically induced Alzheimer Disease - drug therapy Alzheimer Disease - enzymology Amyloid beta-Peptides Animals Drugs, Chinese Herbal - therapeutic use Female Hippocampus - metabolism Male Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Peptide Fragments Phytotherapy Random Allocation Rats Rats, Sprague-Dawley
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	To observe the effect of Naoling decoction on the expression of iNOS in hippocamal CA3 region in rats with Alzheimer's disease (AD), and to explore the potential mechanism. Forty SD rats were classified into 5 groups: a normal group, a sham-operated group, an AD group, a Naoling decoction group, and a Naofukang group. The Alzheimer's disease model was established by injecting Aβ1-42 into the hippocamal in the rats. Expression of iNOS in the CA3 region was measured with immunohistochemical staining. Compared with the normal group, the expression of iNOS protein in the hippocampal CA3 fields in the AD group increased (P
ISSN:	1672-7347
DOI:	10.3969/j.issn.1672-7347.2010.09.002