Opsonic Requirements for Intravascular Clearance after Splenectomy

We investigated the opsonic requirements for intravascular clearance of pneumococci in guinea pigs and of sensitized erythrocytes in human beings after splenectomy. The impaired clearance of injected pneumococci in splenectomized guinea pigs was corrected by immunization. This improvement in clearan...

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Veröffentlicht in:	The New England journal of medicine 1981-01, Vol.304 (5), p.245-250
Hauptverfasser:	Hosea, Stephen W, Brown, Eric J, Hamburger, Max I, Frank, Michael M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Bacterial - immunology Bacterial Infections - etiology Colony-Forming Units Assay Complement C3b - immunology Complement system Complement System Proteins - immunology Erythrocytes Erythrocytes - immunology Female Guinea Pigs Humans Immunity, Innate Immunization Immunoglobulin G Immunoglobulin G - immunology Immunoglobulin M - immunology Laboratories Liver Liver - immunology Macrophages Opsonin Proteins - physiology Opsonization Patients Reticuloendothelial system Sepsis Spleen Splenectomy Splenectomy - adverse effects Streptococcus infections Streptococcus pneumoniae - immunology Thorium
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Zusammenfassung:	We investigated the opsonic requirements for intravascular clearance of pneumococci in guinea pigs and of sensitized erythrocytes in human beings after splenectomy. The impaired clearance of injected pneumococci in splenectomized guinea pigs was corrected by immunization. This improvement in clearance was due to increased hepatic sequestration of organisms. There was a significant delay in antibody-mediated clearance of autologous erythrocytes sensitized with IgG (P
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJM198101293040501