Subtypes of Sodium‐Dependent High‐Affinity L‐[3H]Glutamate Transport Activity: Pharmacologic Specificity and Regulation by Sodium and Potassium

: Some data suggest that the sodium‐dependent, high‐affinity L‐glutamate (Glu) transport sites in forebrain are different from those in cerebellum. In the present study, sodium‐dependent transport of L‐[3H]Glu was characterized in cerebellum and cortex. In both cerebellar and cortical tissue, activi...

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Veröffentlicht in:	Journal of neurochemistry 1993-01, Vol.60 (1), p.167-179
Hauptverfasser:	Robinson, Michael B., Sinor, Jeroo D., Dowd, Lisa A., Kerwin, James F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Biological and medical sciences Biological Transport - drug effects Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Excitatory Amino Acid Antagonists Excitatory amino acids Fundamental and applied biological sciences. Psychology Glutamate Glutamates - pharmacokinetics Glutamic Acid Male Potassium - pharmacology Rats Rats, Sprague-Dawley Sodium - pharmacology Subcellular Fractions - metabolism Transport Tritium Uptake Vertebrates: nervous system and sense organs
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Zusammenfassung:	: Some data suggest that the sodium‐dependent, high‐affinity L‐glutamate (Glu) transport sites in forebrain are different from those in cerebellum. In the present study, sodium‐dependent transport of L‐[3H]Glu was characterized in cerebellum and cortex. In both cerebellar and cortical tissue, activity was enriched in synaptosomes. Approximately 100 excitatory amino acid analogues were tested as potential inhibitors of transport activity. Many of the compounds tested inhibited transport activity by
ISSN:	0022-3042 1471-4159
DOI:	10.1111/j.1471-4159.1993.tb05835.x