Bleomycin-mediated DNA cross-links are dependent on closed-circular molecules with superhelical turns

Non-covalent intermolecular DNA cross-links are created by reaction with the antitumor antibiotic, bleomycin. The cross-links are observed only when the reactant covalently closed circular duplex DNA contains either positive or negative superhelical turns. Multiple sites of cross-linking often exten...

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Veröffentlicht in:	Chemico-biological interactions 1981-02, Vol.34 (1), p.39-46
Hauptverfasser:	Lloyd, R.S., Robberson, D.L., Haidle, C.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriophages Bleomycin - pharmacology Cross-Linking Reagents DNA, Circular - metabolism DNA, Superhelical - metabolism DNA, Viral - metabolism
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Non-covalent intermolecular DNA cross-links are created by reaction with the antitumor antibiotic, bleomycin. The cross-links are observed only when the reactant covalently closed circular duplex DNA contains either positive or negative superhelical turns. Multiple sites of cross-linking often extend over 500 base-pairs or more in length.
ISSN:	0009-2797 1872-7786
DOI:	10.1016/0009-2797(81)90088-0