SYNTHESIS AND BIOLOGICAL ACTIVITY OF A NEW SEMISYNTHETIC CEPHALOSPORIN, CN-92, 982

SYNTHESIS AND BIOLOGICAL ACTIVITY OF A NEW SEMISYNTHETIC CEPHALOSPORIN, CN-92, 982

A new broad spectrum semisynthetic cephalosporin (CN-92, 982) was prepared from the condensation of an acetylaminoacylaminophenyl pyridone with trans-7-[(D-2-phenylglycyl) amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-Δ3-cephem-4-carboxylic acid. The new cephalosporin displayed an in vitro anti...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of antibiotics 1980, Vol.33(11), pp.1352-1356
Hauptverfasser: MICH, T. F., HUANG, G. G., WOO, P. W. K., SANCHEZ, J. P., HEIFETZ, C. L., SCHWEISS, D., KROLLS, U., HUTT, M. P., CULBERTSON, T. P., HASKELL, T. H.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Bacteria - drug effects
Cephalosporins - blood
Cephalosporins - chemical synthesis
Cephalosporins - pharmacology
Dogs
Drug Resistance, Microbial
Kinetics
Mice
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A new broad spectrum semisynthetic cephalosporin (CN-92, 982) was prepared from the condensation of an acetylaminoacylaminophenyl pyridone with trans-7-[(D-2-phenylglycyl) amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-Δ3-cephem-4-carboxylic acid. The new cephalosporin displayed an in vitro antibacterial spectrum similar to other cephaloglycine types such as cefoperazone and SM-1652. The compound produced a high and prolonged blood level following a single intramuscular dose in a dog.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.33.1352