Photoinduced drug release from thermosensitive AuNPs-liposome using a AuNPs-switch

Photoinduced drug release from thermosensitive AuNPs-liposome using a AuNPs-switch

A thermosensitive liposome with embedded AuNPs in a bilayer was prepared using supercritical CO(2). The AuNPs-liposome can absorb a certain wavelength light, convert optical energy into heat, induce phase transition, and release drug. The results show that drug release from the liposome is due to th...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2010-10, Vol.46 (38), p.7202-7204
Hauptverfasser: An, Xueqin, Zhang, Fan, Zhu, Yinyan, Shen, Weiguo
Format: Artikel
Sprache:eng
Schlagworte:
Berberine - administration & dosage
Delayed-Action Preparations - chemistry
Gold - chemistry
Hot Temperature
Liposomes - chemistry
Liposomes - ultrastructure
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Pharmaceutical Preparations - administration & dosage
Phase Transition
Photochemical Processes
Ultraviolet Rays
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Beschreibung
Zusammenfassung:A thermosensitive liposome with embedded AuNPs in a bilayer was prepared using supercritical CO(2). The AuNPs-liposome can absorb a certain wavelength light, convert optical energy into heat, induce phase transition, and release drug. The results show that drug release from the liposome is due to the photothermic effects inducing phase transition of the liposome rather than destruction of the liposome structure.
ISSN:1359-7345
1364-548X
DOI:10.1039/c0cc03142a