Complete Regio- and Stereoselective Construction of Highly Substituted Silyl Enol Ethers by Three-Component Coupling

Three components for total control: Trisubstituted silyl enol ethers were prepared by three‐component coupling of α‐silyl α,β‐unsaturated ketones, organocopper reagents, and organic halides with complete regio‐ and stereoselectivity (see scheme). The reaction proceeded through a 1,3 migration of the silyl group via cyclic silicate intermediates, which controlled the configuration of the silyl enol ethers.