Construction of Robust Bio-nanotubes using the Controlled Self-Assembly of Component Proteins of Bacteriophage T4

The synthesis of a robust bio‐nanotube consisting of the β‐helical tubular component proteins of bacteriophage T4 is described. The crystal structure indicates that it has a well‐defined nanoscale length of 10 nm as a result of the head‐to‐head dimerization of β‐helices. Surprisingly, the tube assem...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2010-09, Vol.6 (17), p.1873-1879
Hauptverfasser:	Yokoi, Norihiko, Inaba, Hiroshi, Terauchi, Makoto, Stieg, Adam Z., Sanghamitra, Nusrat J. M., Koshiyama, Tomomi, Yutani, Katsuhide, Kanamaru, Shuji, Arisaka, Fumio, Hikage, Tatsuo, Suzuki, Atsuo, Yamane, Takashi, Gimzewski, James K., Watanabe, Yoshihito, Kitagawa, Susumu, Ueno, Takafumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteriophage T4 - chemistry Bacteriophage T4 - metabolism Capsid Proteins - chemistry Crystallography, X-Ray Models, Biological Nanotubes Nanotubes - chemistry Protein design Protein engineering Protein Engineering - methods Protein modifications Self-assembly
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Zusammenfassung:	The synthesis of a robust bio‐nanotube consisting of the β‐helical tubular component proteins of bacteriophage T4 is described. The crystal structure indicates that it has a well‐defined nanoscale length of 10 nm as a result of the head‐to‐head dimerization of β‐helices. Surprisingly, the tube assembly has high thermal stability, high tolerance to organic solvents, and a wide pH‐stability range.
ISSN:	1613-6810 1613-6829
DOI:	10.1002/smll.201000772