Risk Factors for Death and Severe Neurological Sequelae in Childhood Bacterial Meningitis in Sub-Saharan Africa

We report a morality rate of 33% among 403 children with bacterial meningitis in Angola. A fatal outcome was associated with impaired consciousness, severe dyspnea, and seizures, and severe neurological sequelae (found in 25% of our patients) was associated with delayed presentation to the hospital,...

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Veröffentlicht in:	Clinical infectious diseases 2009-04, Vol.48 (8), p.1107-1110
Hauptverfasser:	Pelkonen, Tuula, Roine, Irmeli, Monteiro, Lurdes, Correia, Margarida, Pitkäranta, Anne, Bernardino, Luis, Peltola, Heikki
Format:	Artikel
Sprache:	eng
Schlagworte:	Africa South of the Sahara - epidemiology Angola Anti-Bacterial Agents - therapeutic use Bacteria Bacterial diseases Bacterial diseases of the nervous system. Bacterial myositis Bacterial meningitis Biological and medical sciences Brief Reports Child Child development Child, Preschool Childhood Children Children & youth Consciousness Disorders - etiology Death & dying Drug therapy Dyspnea - etiology Health outcomes Hospital admissions Human bacterial diseases Humans Infant Infectious diseases Logistic Models Medical sciences Meningitis Meningitis, Bacterial - complications Meningitis, Bacterial - drug therapy Meningitis, Bacterial - mortality Meningitis, Bacterial - physiopathology Meningococcal meningitis Mortality Multivariate Analysis Neurology Pneumococcal meningitis Predisposing factors Risk Factors Seizures Seizures - etiology Teaching hospitals Treatment Outcome
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Zusammenfassung:	We report a morality rate of 33% among 403 children with bacterial meningitis in Angola. A fatal outcome was associated with impaired consciousness, severe dyspnea, and seizures, and severe neurological sequelae (found in 25% of our patients) was associated with delayed presentation to the hospital, impaired consciousness, and seizures. Being underweight was of secondary importance. Treatment with ceftriaxone, rather than with penicillin plus chloramphenicol, did not improve outcome.
ISSN:	1058-4838 1537-6591
DOI:	10.1086/597463