Response-Guided Therapy for Chronic Hepatitis C Virus Infection in Patients Coinfected with HIV: A Pilot Trial

Background. To study the feasibility of a response-guided therapy for chronic hepatitis C virus (HCV) infection in patients coinfected with human immunodeficiency virus (HIV) in a tertiary care hospital. Methods. Treatment duration was individualized on the basis of week 4 and week 12 virologic resp...

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Veröffentlicht in:	Clinical infectious diseases 2009-04, Vol.48 (8), p.1152-1159
Hauptverfasser:	Van den Eynde, Eva, Crespo, Manuel, Esteban, Juan I., Jardi, Rosend, Ribera, Esteban, Carbonell, Judit, Rodríguez-Frias, Francisco, Falco, Vicenç, Curran, Adrià, Imaz, Arkaitz, Villar del Saz, Sara, Ocaña, Inma, Esteban, Rafael, Pahissa, Albert
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis of Variance Antiviral Agents - adverse effects Antiviral Agents - therapeutic use Biological and medical sciences Chi-Square Distribution Chronic hepatitis Feasibility Female Genotype Genotypes Hepacivirus - drug effects Hepacivirus - genetics Hepacivirus - isolation & purification Hepatitis Hepatitis C Hepatitis C virus Hepatitis C, Chronic - complications Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - virology HIV HIV Infections - complications HIV/AIDS Hospitalization Hospitals Human immunodeficiency virus Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infections Infectious diseases Interferon-alpha - adverse effects Interferon-alpha - therapeutic use Interferons Male Medical sciences Middle Aged Patients Pilot Projects Polyethylene Glycols - adverse effects Polyethylene Glycols - therapeutic use Recombinant Proteins Relapse Ribavirin - adverse effects Ribavirin - therapeutic use Ribonucleic acid RNA RNA, Viral - blood Statistics, Nonparametric Treatment Outcome Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral hepatitis Viral Load Virology Viruses
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Zusammenfassung:	Background. To study the feasibility of a response-guided therapy for chronic hepatitis C virus (HCV) infection in patients coinfected with human immunodeficiency virus (HIV) in a tertiary care hospital. Methods. Treatment duration was individualized on the basis of week 4 and week 12 virologic response. Sixty patients were enrolled and received pegylated interferon alfa-2b (1.5 μg/kg per week) plus weight-based ribavirin (800–1400 mg/day). Patients who achieved a rapid virologic response, defined as viral load
ISSN:	1058-4838 1537-6591
DOI:	10.1086/597470