TGF-b sub(1), IL-10 and IL-4 in colostrum of allergic and nonallergic mothers

Objective: To determine transforming growth factor (TGF) b sub(1), interleukin (IL) 4, and IL-10 concentrations in human milk and to assess the relationship between allergic disorders in mothers and the content of the interleukins in their milk. Material and methods: Thirty allergic and 46 healthy mothers were included in the study. Colostrum was collected 2-3 days after delivery. Cytokine concentrations were determined with commercial enzyme-linked immunosorbent systems. Results: TGF-b sub(1) was found in milk from 23 women in the control group (53.49%) and 11 in the allergy group (37.93%). When TGF-b sub(1) was present, the median concentration was higher in the allergy group than in the control (61.5 and 30.4 pg/mL, respectively; P