Low-Level Viremia Associated With the Use of TaqMan Assay

Poor correlation has been reported between the Roche Cobas AmpliPrep/Cobas (TaqMan) HIV-1 TaqMan assay and the Roche Cobas Amplicor HIV-1 Monitor version 1.5 Amplicor assay. We report 8 patients who experienced unexplained detectable viremia, despite exemplary medication adherence, following a chang...

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Veröffentlicht in:	Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) Ill. : 2002), 2010-07, Vol.9 (4), p.203-205
Hauptverfasser:	Szabo, Susan, Moffett, Lee E., Cantwell- McNelis, Kelly, James, Christopher W., Joseph, Abraham
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anti-Retroviral Agents - pharmacology Anti-Retroviral Agents - therapeutic use Antiretroviral drugs Branched DNA Signal Amplification Assay Female HIV HIV Infections - drug therapy HIV Infections - virology HIV-1 - drug effects HIV-1 - isolation & purification HIV-1 - physiology Human immunodeficiency virus Human immunodeficiency virus 1 Humans Male Middle Aged Patients Polymerase Chain Reaction - methods Reagent Kits, Diagnostic RNA, Viral - blood Sensitivity and Specificity Taq Polymerase Viral Load - physiology Viremia - drug therapy Viremia - virology
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Zusammenfassung:	Poor correlation has been reported between the Roche Cobas AmpliPrep/Cobas (TaqMan) HIV-1 TaqMan assay and the Roche Cobas Amplicor HIV-1 Monitor version 1.5 Amplicor assay. We report 8 patients who experienced unexplained detectable viremia, despite exemplary medication adherence, following a change in viral quantification assay from Amplicor to TaqMan in January 2008. All patients were found to have undetectable HIV RNA by branched DNA (bDNA) assay.
ISSN:	1545-1097 2325-9574 1557-0886 2325-9582
DOI:	10.1177/1545109710371131