The relationship between albuminuria, MCP-1/CCL2, and interstitial macrophages in chronic kidney disease

Glomerular-derived proteins may activate tubular cells to express the macrophage-directed chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2). Macrophages at interstitial sites have a central role in directing renal scarring. We have prospectively assessed the relationship between albuminuria,...

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Veröffentlicht in:	Kidney international 2006-04, Vol.69 (7), p.1189-1197
Hauptverfasser:	Eardley, K.S., Zehnder, D., Quinkler, M., Lepenies, J., Bates, R.L., Savage, C.O., Howie, A.J., Adu, D., Cockwell, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Albuminuria Biological and medical sciences Cell Count Chemokine CCL2 - genetics Chemokine CCL2 - urine Chronic Disease chronic kidney disease Disease Progression Humans Immunoglobulin A - analysis Immunoglobulin G - analysis Immunoglobulin M - analysis Immunohistochemistry Kidney Diseases - immunology Kidney Diseases - physiopathology Kidney Diseases - urine Kidneys macrophages Macrophages - pathology Macrophages - physiology MCP-1/CCL2 Medical sciences Nephrology. Urinary tract diseases Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland
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Zusammenfassung:	Glomerular-derived proteins may activate tubular cells to express the macrophage-directed chemokine monocyte chemoattractant protein-1 (MCP-1/CCL2). Macrophages at interstitial sites have a central role in directing renal scarring. We have prospectively assessed the relationship between albuminuria, urinary MCP-1/CCL2, interstitial macrophage infiltration, in situ damage, and clinical outcomes in a large group of patients with chronic kidney disease. We studied 215 patients and quantified albumin–creatinine ratio (ACR), urinary MCP-1/CCL2, interstitial macrophage numbers, and in situ damage. ACR correlated with urinary MCP-1/CCL2 (correlation 0.499; P
ISSN:	0085-2538 1523-1755
DOI:	10.1038/sj.ki.5000212