Hyponatremia with hypoxia: Effects on brain adaptation, perfusion, and histology in rodents

Hypoxia appears to be a prominent component of brain damage among patients with hyponatremic encephalopathy. Effects of hypoxia on brain in the presence of hyponatremia are not known. In order to evaluate the contributions of hypoxia to brain damage, three separate experiments were conducted in thre...

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Veröffentlicht in:	Kidney international 2006-04, Vol.69 (8), p.1319-1325
Hauptverfasser:	Ayus, J.C., Armstrong, D., Arieff, A.I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological Animals Brain - metabolism Brain - pathology Brain Damage, Chronic - etiology Brain Damage, Chronic - pathology brain histopathology cerebral edema cerebral perfusion hyponatremia Hyponatremia - complications Hyponatremia - mortality Hyponatremia - pathology hypoxia Hypoxia, Brain - complications Hypoxia, Brain - etiology Hypoxia, Brain - pathology hypoxic brain damage Immunohistochemistry Magnetic Resonance Imaging Male Models, Anatomic Perfusion Rats Rats, Sprague-Dawley
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Zusammenfassung:	Hypoxia appears to be a prominent component of brain damage among patients with hyponatremic encephalopathy. Effects of hypoxia on brain in the presence of hyponatremia are not known. In order to evaluate the contributions of hypoxia to brain damage, three separate experiments were conducted in three groups of rodents. Experiment I evaluated the effects of hypoxia and acute (
ISSN:	0085-2538 1523-1755
DOI:	10.1038/sj.ki.5000187