Currarino syndrome as an etiology of a neonatal Escherichia coli meningitis

We report the case of a 29-day-old baby girl in whom Escherichia coli meningitis led to the diagnosis of Currarino syndrome (CS) (OMIM 176450), an autosomal-dominant genetic disorder associated with sacral agenesis, anorectal malformation, presacral masses and spinal cord malformations. Her conditio...

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Veröffentlicht in:	Journal of perinatology 2007-09, Vol.27 (9), p.589-591
Hauptverfasser:	Fleury, J, Picherot, G, Cretolle, C, Podevin, G, David, A, Caillon, J, Roze, J C, Gras-le Guen, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Multiple Anorectal Antibiotics Autosomal dominant inheritance Bacterial meningitis Care and treatment Case studies Complications and side effects Congenital defects Diagnosis E coli Escherichia coli Etiology Female Gene mutations Genetic disorders Health aspects Hereditary diseases Humans Infant, Newborn Meningitis Meningitis, Escherichia coli - etiology Neonates Newborn babies Rectum - abnormalities Sacrum Sacrum - abnormalities Spinal cord Syndrome
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Zusammenfassung:	We report the case of a 29-day-old baby girl in whom Escherichia coli meningitis led to the diagnosis of Currarino syndrome (CS) (OMIM 176450), an autosomal-dominant genetic disorder associated with sacral agenesis, anorectal malformation, presacral masses and spinal cord malformations. Her condition improved with antibiotics and early surgical treatment. A familial study identified other genetically related individuals with similar symptoms.
ISSN:	0743-8346 1476-5543
DOI:	10.1038/sj.jp.7211783