RNA inhibits estrogen receptor binding to DNA
Cytosol from MTW9 rat mammary tumor contains a high molecular weight inhibitor of estrogen receptor binding to DNA. RNase treatment of crude preparations destroys inhibitory activity, whereas DNase or trypsin treatment are without affect, suggesting that some RNA molecule might be involved; in addit...
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| Veröffentlicht in: | The Journal of biological chemistry 1981-02, Vol.256 (3), p.1145-1148 |
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| container_title | The Journal of biological chemistry |
| container_volume | 256 |
| creator | Feldman, M Kallos, J Hollander, V P |
| description | Cytosol from MTW9 rat mammary tumor contains a high molecular weight inhibitor of estrogen receptor binding to DNA. RNase
treatment of crude preparations destroys inhibitory activity, whereas DNase or trypsin treatment are without affect, suggesting
that some RNA molecule might be involved; in addition, RNA extracted from tumor cytosol was an effective inhibitor of estrogen
receptor binding to DNA. A number of synthetic and natural RNA species were analyzed for inhibitory activity; a definite specificity
was observed, with poly(G) > poly(U) > poly(A) or poly(C). |
| doi_str_mv | 10.1016/S0021-9258(19)69940-0 |
| format | Article |
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treatment of crude preparations destroys inhibitory activity, whereas DNase or trypsin treatment are without affect, suggesting
that some RNA molecule might be involved; in addition, RNA extracted from tumor cytosol was an effective inhibitor of estrogen
receptor binding to DNA. A number of synthetic and natural RNA species were analyzed for inhibitory activity; a definite specificity
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treatment of crude preparations destroys inhibitory activity, whereas DNase or trypsin treatment are without affect, suggesting
that some RNA molecule might be involved; in addition, RNA extracted from tumor cytosol was an effective inhibitor of estrogen
receptor binding to DNA. A number of synthetic and natural RNA species were analyzed for inhibitory activity; a definite specificity
was observed, with poly(G) > poly(U) > poly(A) or poly(C).</description><subject>Animals</subject><subject>Cell Line</subject><subject>Chromatography, Affinity</subject><subject>Cytosol - metabolism</subject><subject>Deoxyribonucleases</subject><subject>DNA - metabolism</subject><subject>Female</subject><subject>Kinetics</subject><subject>Mammary Neoplasms, Experimental - metabolism</subject><subject>Polyribonucleotides - pharmacology</subject><subject>Protein Binding</subject><subject>Rats</subject><subject>Receptors, Estrogen - isolation & purification</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Ribonucleases</subject><subject>RNA, Neoplasm - metabolism</subject><subject>Trypsin</subject><issn>0021-9258</issn><issn>1083-351X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtPwzAQhC0EKqXwEypFHBAcAt7EduxjVZ5SVSQeEjcrdjaNUZMUOxXi35M-1L3sYWZ2Rx8hY6C3QEHcvVOaQKwSLq9B3QilGI3pERkClWmccvg6JsOD5ZSchfBN-2EKBmSQMQ5MiSGJ3-aTyDWVM64LEYbOtwtsIo8WV13rI-OawjWLqGuj-_nknJyU-TLgxX6PyOfjw8f0OZ69Pr1MJ7PYppnsYs4lmgINFIXAnLG8MKlCmzFa5BlIUEIYpXJbgpFYcigFTyTNwVJZUgEqHZGr3d2Vb3_WfStdu2BxucwbbNdBZ5xTBYnojXxntL4NwWOpV97Vuf_TQPUGk95i0hsGGpTeYtK0z433D9amxuKQ2nPp9cudXrlF9es8auNaW2GtEy50qgEYT_8BN1JtJQ</recordid><startdate>19810210</startdate><enddate>19810210</enddate><creator>Feldman, M</creator><creator>Kallos, J</creator><creator>Hollander, V P</creator><general>American Society for Biochemistry and Molecular Biology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19810210</creationdate><title>RNA inhibits estrogen receptor binding to DNA</title><author>Feldman, M ; Kallos, J ; Hollander, V P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c378t-558ebdeb1dd6ea44adb39ec740da7181966b99acf1b8ef51f65280a1c08f06193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Animals</topic><topic>Cell Line</topic><topic>Chromatography, Affinity</topic><topic>Cytosol - metabolism</topic><topic>Deoxyribonucleases</topic><topic>DNA - metabolism</topic><topic>Female</topic><topic>Kinetics</topic><topic>Mammary Neoplasms, Experimental - metabolism</topic><topic>Polyribonucleotides - pharmacology</topic><topic>Protein Binding</topic><topic>Rats</topic><topic>Receptors, Estrogen - isolation & purification</topic><topic>Receptors, Estrogen - metabolism</topic><topic>Ribonucleases</topic><topic>RNA, Neoplasm - metabolism</topic><topic>Trypsin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feldman, M</creatorcontrib><creatorcontrib>Kallos, J</creatorcontrib><creatorcontrib>Hollander, V P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feldman, M</au><au>Kallos, J</au><au>Hollander, V P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>RNA inhibits estrogen receptor binding to DNA</atitle><jtitle>The Journal of biological chemistry</jtitle><addtitle>J Biol Chem</addtitle><date>1981-02-10</date><risdate>1981</risdate><volume>256</volume><issue>3</issue><spage>1145</spage><epage>1148</epage><pages>1145-1148</pages><issn>0021-9258</issn><eissn>1083-351X</eissn><abstract>Cytosol from MTW9 rat mammary tumor contains a high molecular weight inhibitor of estrogen receptor binding to DNA. RNase
treatment of crude preparations destroys inhibitory activity, whereas DNase or trypsin treatment are without affect, suggesting
that some RNA molecule might be involved; in addition, RNA extracted from tumor cytosol was an effective inhibitor of estrogen
receptor binding to DNA. A number of synthetic and natural RNA species were analyzed for inhibitory activity; a definite specificity
was observed, with poly(G) > poly(U) > poly(A) or poly(C).</abstract><cop>United States</cop><pub>American Society for Biochemistry and Molecular Biology</pub><pmid>7451496</pmid><doi>10.1016/S0021-9258(19)69940-0</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of biological chemistry, 1981-02, Vol.256 (3), p.1145-1148 |
| issn | 0021-9258 1083-351X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_75509126 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Cell Line Chromatography, Affinity Cytosol - metabolism Deoxyribonucleases DNA - metabolism Female Kinetics Mammary Neoplasms, Experimental - metabolism Polyribonucleotides - pharmacology Protein Binding Rats Receptors, Estrogen - isolation & purification Receptors, Estrogen - metabolism Ribonucleases RNA, Neoplasm - metabolism Trypsin |
| title | RNA inhibits estrogen receptor binding to DNA |
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