Pre‐Clinical Safety Evaluation of Pyrrolidine Dithiocarbamate

:  Pyrrolidine dithiocarbamate (PDTC) was examined for its potential in the intranasal treatment of human rhinovirus infections. Prior to clinical testing, a comprehensive non‐clinical programme was performed to evaluate the general toxicity of PDTC. The animal experiments included investigations in...

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Veröffentlicht in:Basic & clinical pharmacology & toxicology 2010-09, Vol.107 (3), p.758-767
Hauptverfasser: Chabicovsky, Monika, Prieschl‐Grassauer, Eva, Seipelt, Joachim, Muster, Thomas, Szolar, Oliver H. J., Hebar, Alexandra, Doblhoff‐Dier, Otto
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Sprache:eng
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Zusammenfassung::  Pyrrolidine dithiocarbamate (PDTC) was examined for its potential in the intranasal treatment of human rhinovirus infections. Prior to clinical testing, a comprehensive non‐clinical programme was performed to evaluate the general toxicity of PDTC. The animal experiments included investigations in rodents with study durations ranging from single dose to repeated dosing over a period of 28 days. The routes of administration were intranasal, inhalative, oral and intravenous for single‐dose toxicity and pharmacokinetic studies, and intranasal for repeated dose studies. Blood and tissue samples were obtained from PDTC‐treated rats to analyse pharmacokinetics and tissue distribution. Accumulation of selected metals due to PDTC treatment was examined in liver, brain, nerves and fat tissues.
ISSN:1742-7835
1742-7843
DOI:10.1111/j.1742-7843.2010.00573.x