Does monosomy 5 really exist in myelodysplastic syndromes and acute myeloid leukemia?
Abstract Abnormalities of chromosome 5 are common aberrations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), being del(5q) the most frequent. In contrast, monosomy 5 is not so frequent and, usually, is associated with complex karyotypes, conferring poor prognosis. The aim of th...
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| Veröffentlicht in: | Leukemia research 2010-09, Vol.34 (9), p.1242-1245 |
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| creator | Galván, Ana Belén Mallo, Mar Arenillas, Leonor Salido, Marta Espinet, Blanca Pedro, Carmen Florensa, Lourdes Serrano, Sergi Solé, Francesc |
| description | Abstract Abnormalities of chromosome 5 are common aberrations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), being del(5q) the most frequent. In contrast, monosomy 5 is not so frequent and, usually, is associated with complex karyotypes, conferring poor prognosis. The aim of this study was to analyze, by FISH for 5q31 (EGR1), a series of 28 MDS and AML cases with monosomy 5 detected by G-banding. FISH results revealed deletion of 5q31 in 24 of them (85.7%) and monosomy 5 just in three. FISH for 5q31 can complement conventional cytogenetics and improve the karyotype definition, leading to a better diagnostic and prognostic stratification. |
| doi_str_mv | 10.1016/j.leukres.2010.03.022 |
| format | Article |
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In contrast, monosomy 5 is not so frequent and, usually, is associated with complex karyotypes, conferring poor prognosis. The aim of this study was to analyze, by FISH for 5q31 (EGR1), a series of 28 MDS and AML cases with monosomy 5 detected by G-banding. FISH results revealed deletion of 5q31 in 24 of them (85.7%) and monosomy 5 just in three. FISH for 5q31 can complement conventional cytogenetics and improve the karyotype definition, leading to a better diagnostic and prognostic stratification.</description><identifier>ISSN: 0145-2126</identifier><identifier>EISSN: 1873-5835</identifier><identifier>DOI: 10.1016/j.leukres.2010.03.022</identifier><identifier>PMID: 20362335</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>5q deletion ; Acute myeloid leukemia ; Chromosomes, Human, Pair 5 ; FISH ; Hematology, Oncology and Palliative Medicine ; Humans ; Karyotype ; Karyotyping ; Leukemia, Myeloid, Acute - genetics ; Monosomy ; Monosomy 5 ; Myelodysplastic syndrome ; Myelodysplastic Syndromes - genetics</subject><ispartof>Leukemia research, 2010-09, Vol.34 (9), p.1242-1245</ispartof><rights>Elsevier Ltd</rights><rights>2010 Elsevier Ltd</rights><rights>Copyright 2010 Elsevier Ltd. 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FISH for 5q31 can complement conventional cytogenetics and improve the karyotype definition, leading to a better diagnostic and prognostic stratification.</description><subject>5q deletion</subject><subject>Acute myeloid leukemia</subject><subject>Chromosomes, Human, Pair 5</subject><subject>FISH</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Karyotype</subject><subject>Karyotyping</subject><subject>Leukemia, Myeloid, Acute - genetics</subject><subject>Monosomy</subject><subject>Monosomy 5</subject><subject>Myelodysplastic syndrome</subject><subject>Myelodysplastic Syndromes - genetics</subject><issn>0145-2126</issn><issn>1873-5835</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1q3DAUhUVoSCZpH6FFu6481b_lTUNJfyGQRZu1kKU7oIlsTSU7xG9fmZl20U1Wgst37hXfQegtJVtKqPqw30aYHzOULSN1RviWMHaGNlS3vJGay1doQ6iQDaNMXaKrUvaEENnR7gJdMsIV41xu0MPnBAUPaUwlDQuWOIONccHwHMqEw4iHBWLySzlEW6bgcFlGn9NQQ3b02Lp5giMTPF5_BEOwN6_R-c7GAm9O7zV6-Prl1-335u7-24_bT3eNk7SdGilsz1ynre0pML5zvVXMCqdaDa1iwolWe-e44lTsqLedal2vieZM9L0nHb9G7497Dzn9nqFMZgjFQYx2hDQX00qhO0U6-TJZQaa54JWUR9LlVEqGnTnkMNi8GErMqt7szUm9WdUbwk1VX3PvThfmfgD_L_XXdQVujgBUI08BsikuwOjAhwxuMj6FF098_G-Di2EMzsZHWKDs05zHqttQU5gh5ufa_1o_rc1TxTn_A1wLrR0</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Galván, Ana Belén</creator><creator>Mallo, Mar</creator><creator>Arenillas, Leonor</creator><creator>Salido, Marta</creator><creator>Espinet, Blanca</creator><creator>Pedro, Carmen</creator><creator>Florensa, Lourdes</creator><creator>Serrano, Sergi</creator><creator>Solé, Francesc</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20100901</creationdate><title>Does monosomy 5 really exist in myelodysplastic syndromes and acute myeloid leukemia?</title><author>Galván, Ana Belén ; Mallo, Mar ; Arenillas, Leonor ; Salido, Marta ; Espinet, Blanca ; Pedro, Carmen ; Florensa, Lourdes ; Serrano, Sergi ; Solé, Francesc</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-54ab2c98aab1e23fcba62a4c678e7624c478dcc36314f1da967cb808324bbd093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>5q deletion</topic><topic>Acute myeloid leukemia</topic><topic>Chromosomes, Human, Pair 5</topic><topic>FISH</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Karyotype</topic><topic>Karyotyping</topic><topic>Leukemia, Myeloid, Acute - genetics</topic><topic>Monosomy</topic><topic>Monosomy 5</topic><topic>Myelodysplastic syndrome</topic><topic>Myelodysplastic Syndromes - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Galván, Ana Belén</creatorcontrib><creatorcontrib>Mallo, Mar</creatorcontrib><creatorcontrib>Arenillas, Leonor</creatorcontrib><creatorcontrib>Salido, Marta</creatorcontrib><creatorcontrib>Espinet, Blanca</creatorcontrib><creatorcontrib>Pedro, Carmen</creatorcontrib><creatorcontrib>Florensa, Lourdes</creatorcontrib><creatorcontrib>Serrano, Sergi</creatorcontrib><creatorcontrib>Solé, Francesc</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Leukemia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Galván, Ana Belén</au><au>Mallo, Mar</au><au>Arenillas, Leonor</au><au>Salido, Marta</au><au>Espinet, Blanca</au><au>Pedro, Carmen</au><au>Florensa, Lourdes</au><au>Serrano, Sergi</au><au>Solé, Francesc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does monosomy 5 really exist in myelodysplastic syndromes and acute myeloid leukemia?</atitle><jtitle>Leukemia research</jtitle><addtitle>Leuk Res</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>34</volume><issue>9</issue><spage>1242</spage><epage>1245</epage><pages>1242-1245</pages><issn>0145-2126</issn><eissn>1873-5835</eissn><abstract>Abstract Abnormalities of chromosome 5 are common aberrations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), being del(5q) the most frequent. In contrast, monosomy 5 is not so frequent and, usually, is associated with complex karyotypes, conferring poor prognosis. The aim of this study was to analyze, by FISH for 5q31 (EGR1), a series of 28 MDS and AML cases with monosomy 5 detected by G-banding. FISH results revealed deletion of 5q31 in 24 of them (85.7%) and monosomy 5 just in three. FISH for 5q31 can complement conventional cytogenetics and improve the karyotype definition, leading to a better diagnostic and prognostic stratification.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>20362335</pmid><doi>10.1016/j.leukres.2010.03.022</doi><tpages>4</tpages></addata></record> |
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| subjects | 5q deletion Acute myeloid leukemia Chromosomes, Human, Pair 5 FISH Hematology, Oncology and Palliative Medicine Humans Karyotype Karyotyping Leukemia, Myeloid, Acute - genetics Monosomy Monosomy 5 Myelodysplastic syndrome Myelodysplastic Syndromes - genetics |
| title | Does monosomy 5 really exist in myelodysplastic syndromes and acute myeloid leukemia? |
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