Does monosomy 5 really exist in myelodysplastic syndromes and acute myeloid leukemia?

Abstract Abnormalities of chromosome 5 are common aberrations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), being del(5q) the most frequent. In contrast, monosomy 5 is not so frequent and, usually, is associated with complex karyotypes, conferring poor prognosis. The aim of th...

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Veröffentlicht in:	Leukemia research 2010-09, Vol.34 (9), p.1242-1245
Hauptverfasser:	Galván, Ana Belén, Mallo, Mar, Arenillas, Leonor, Salido, Marta, Espinet, Blanca, Pedro, Carmen, Florensa, Lourdes, Serrano, Sergi, Solé, Francesc
Format:	Artikel
Sprache:	eng
Schlagworte:	5q deletion Acute myeloid leukemia Chromosomes, Human, Pair 5 FISH Hematology, Oncology and Palliative Medicine Humans Karyotype Karyotyping Leukemia, Myeloid, Acute - genetics Monosomy Monosomy 5 Myelodysplastic syndrome Myelodysplastic Syndromes - genetics
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Zusammenfassung:	Abstract Abnormalities of chromosome 5 are common aberrations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), being del(5q) the most frequent. In contrast, monosomy 5 is not so frequent and, usually, is associated with complex karyotypes, conferring poor prognosis. The aim of this study was to analyze, by FISH for 5q31 (EGR1), a series of 28 MDS and AML cases with monosomy 5 detected by G-banding. FISH results revealed deletion of 5q31 in 24 of them (85.7%) and monosomy 5 just in three. FISH for 5q31 can complement conventional cytogenetics and improve the karyotype definition, leading to a better diagnostic and prognostic stratification.
ISSN:	0145-2126 1873-5835
DOI:	10.1016/j.leukres.2010.03.022