Successful treatment of primary non-Hodgkin's lymphoma of the vagina with chemotherapy

The vagina as a primary site of malignant lymphoma in woman is extremely rare. We report here a 30-year-old patient with a primary vaginal non-Hodgkin's lymphoma stage IEA, follicular large cell of B lineage, with an excellent response to cytotoxic chemotherapy (CHOP) and event-free survival of 28 months. Primary involvement of the vagina can be successfully treated by pelvic irradiation, but in young women chemotherapy should be considered to preserve fertility, as well as quality of life.