Immune reconstitution inflammatory syndrome due to Mycobacterium bovis Bacillus Calmette-Guerin in infants receiving highly active antiretroviral therapy: a call for universal perinatal rapid HIV testing prior to administration of BCG immunization of neonates

The evidence behind the World Health Organization guidelines that BCG vaccination should not be used in HIV-infected children is compelling. We report three cases of severe BCG-associated immune reconstitution syndrome in HIV-infected infants and describe measures available in developing countries t...

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Veröffentlicht in:	Journal of tropical pediatrics (1980) 2010-08, Vol.56 (4), p.280-283
Hauptverfasser:	Koppel, Alexander, Leonardo-Guerrero, Jose, Rives, Sarah, Paniagua-Torres, Noemí, Sparrow, Celine, Beck-Sagué, Consuelo M
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS-Related Opportunistic Infections - chemically induced AIDS-Related Opportunistic Infections - immunology Antiretroviral Therapy, Highly Active - adverse effects BCG Vaccine - adverse effects BCG Vaccine - immunology Female Guidelines as Topic HIV Infections - complications HIV Infections - drug therapy HIV Infections - immunology Human immunodeficiency virus Humans Immune Reconstitution Inflammatory Syndrome - chemically induced Immunization Infant Male Mycobacterium bovis World Health Organization
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Zusammenfassung:	The evidence behind the World Health Organization guidelines that BCG vaccination should not be used in HIV-infected children is compelling. We report three cases of severe BCG-associated immune reconstitution syndrome in HIV-infected infants and describe measures available in developing countries that prevent inadvertent BCG immunization in these infants.
ISSN:	0142-6338 1465-3664
DOI:	10.1093/tropej/fmp115