Vascular endothelial growth factor in esophageal cancer

Vascular endothelial growth factor (VEGF) plays a crucial role in angiogenesis of many solid malignancies. The influence of angiogenesis and VEGF expression on progression and recurrence of esophageal cancer has been investigated over the last years. This article reviews the prognostic significance...

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Veröffentlicht in:	Journal of surgical oncology 2004-08, Vol.87 (2), p.95-104
Hauptverfasser:	Kleespies, Axel, Guba, Markus, Jauch, Karl-Walter, Bruns, Christiane J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - blood supply Adenocarcinoma - metabolism Adenocarcinoma - pathology anti-angiogenic therapy Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Barrett Esophagus - metabolism Barrett's disease Bevacizumab Carcinoma, Squamous Cell - blood supply Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Esophageal Neoplasms - blood supply Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology esophagus Humans Indoles - therapeutic use Lymphangiogenesis Neovascularization, Pathologic - metabolism Prognosis Protein-Tyrosine Kinases - antagonists & inhibitors Pyrroles - therapeutic use RNA, Catalytic - therapeutic use RNA, Messenger - biosynthesis Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - biosynthesis VEGF VEGF-C
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Zusammenfassung:	Vascular endothelial growth factor (VEGF) plays a crucial role in angiogenesis of many solid malignancies. The influence of angiogenesis and VEGF expression on progression and recurrence of esophageal cancer has been investigated over the last years. This article reviews the prognostic significance of VEGF expression, microvessel density (MVD), and lymphangiogenic factors in squamous cell carcinoma (SCC), Barrett's dysplasia, and adenocarcinoma (AC) of the esophagus, their predictive value for treatment response to chemo‐radiotherapy and new anti‐angiogenic treatment strategies. J. Surg. Oncol. 2004;87:95–104. © 2004 Wiley‐Liss, Inc.
ISSN:	0022-4790 1096-9098
DOI:	10.1002/jso.20070