Oral pulsed high-dose dexamethasone for myositis

To study the short-term effect of oral pulsed high-dose dexamethasone for myositis we treated eight newly diagnosed patients with three 28-day cycles of oral dexamethasone. Primary outcome measures were muscle strength, pain, and serum creatine kinase activity. Six patients responded. Side effects w...

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Veröffentlicht in:	Journal of neurology 2000-02, Vol.247 (2), p.102-105
Hauptverfasser:	VAN DER MEULEN, M. F. G, HOOGENDIJK, J. E, WOKKE, J. H. J, DE VISSER, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Biological and medical sciences Biopsy Breast cancer Dexamethasone - administration & dosage Disease Dysphagia Female Hormones. Endocrine system Humans Male Medical research Medical sciences Middle Aged Muscle pain Muscle strength Myositis - drug therapy Neurology Patients Pharmacology. Drug treatments Pulse Therapy, Drug Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Skin Steroids
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Zusammenfassung:	To study the short-term effect of oral pulsed high-dose dexamethasone for myositis we treated eight newly diagnosed patients with three 28-day cycles of oral dexamethasone. Primary outcome measures were muscle strength, pain, and serum creatine kinase activity. Six patients responded. Side effects were mild. At follow-up five responders were still in remission, without medication. Pulsed high-dose dexamethasone seems beneficial in myositis. A larger, prednisone-controlled trial is justified to analyze long-term efficacy.
ISSN:	0340-5354 1432-1459
DOI:	10.1007/PL00007789