Can we predict flu-like symptoms in patients with multiple sclerosis treated with interferon-β ?

Can we predict flu-like symptoms in patients with multiple sclerosis treated with interferon-β ?

Interferon-beta1b treatment in relapsing-remitting multiple sclerosis can frequently induce systemic side effects such as flu-like symptoms with fever. In vitro stimulation of peripheral blood leukocytes with interferon-beta1b before the beginning of therapy shows that patients who develop fever gen...

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Veröffentlicht in:Journal of neurology 2000-04, Vol.247 (4), p.259-262
Hauptverfasser: MONTALBAN, X, DURAN, I, RIO, J, SAEZ-TORRES, I, TINTORE, M, MARTINEZ-CACERES, E. M
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Biological and medical sciences
Cohort Studies
Female
Flow Cytometry
Humans
In Vitro Techniques
Influenza, Human - complications
Interferon-beta - therapeutic use
Interleukin-10 - blood
Interleukin-6 - blood
Male
Medical sciences
Multiple Sclerosis - complications
Multiple Sclerosis - drug therapy
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Predictive Value of Tests
Retrospective Studies
Tumor Necrosis Factor-alpha - metabolism
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Zusammenfassung:Interferon-beta1b treatment in relapsing-remitting multiple sclerosis can frequently induce systemic side effects such as flu-like symptoms with fever. In vitro stimulation of peripheral blood leukocytes with interferon-beta1b before the beginning of therapy shows that patients who develop fever generally have increased levels of interleukin-6.
ISSN:0340-5354
1432-1459
DOI:10.1007/s004150050580