The effects of a nucleoside-sparing antiretroviral regimen on the pharmacokinetics of ritonavir-boosted darunavir in HIV type-1-infected patients

Nucleoside-sparing combination antiretroviral therapy (cART) regimens might be an attractive therapeutic option for HIV type-1 (HIV-1)-infected patients; however, the pharmacokinetic profiles of such regimens are frequently unknown. Fourteen HIV-1-infected patients (age 21-55 years, 64% male) on sta...

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Veröffentlicht in:	Antiviral therapy 2010-01, Vol.15 (2), p.213-218
Hauptverfasser:	GARVEY, Lucy, LATCH, Ngaire, ERLWEIN, Otto W, MACKIE, Nicola E, WALSH, John, SCULLARD, George, MCCLURE, Myra O, DICKINSON, Laura, BACK, David, WINSTON, Alan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - administration & dosage Adenine - analogs & derivatives Adenine - therapeutic use Adult Anti-HIV Agents - administration & dosage Anti-HIV Agents - pharmacokinetics Anti-HIV Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Darunavir Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use Drug Administration Schedule Drug Interactions Drug Therapy, Combination Emtricitabine Female HIV Infections - drug therapy HIV Infections - virology HIV Protease Inhibitors - administration & dosage HIV Protease Inhibitors - pharmacokinetics HIV Protease Inhibitors - therapeutic use HIV-1 - drug effects Human immunodeficiency virus Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Male Medical sciences Middle Aged Organophosphonates - administration & dosage Organophosphonates - therapeutic use Pharmacology. Drug treatments Pyrrolidinones - administration & dosage Pyrrolidinones - therapeutic use Raltegravir Potassium Reverse Transcriptase Inhibitors - administration & dosage Reverse Transcriptase Inhibitors - therapeutic use Ritonavir - administration & dosage Ritonavir - pharmacokinetics Ritonavir - therapeutic use Sulfonamides - administration & dosage Sulfonamides - pharmacokinetics Sulfonamides - therapeutic use Tenofovir Treatment Outcome Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Young Adult
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Zusammenfassung:	Nucleoside-sparing combination antiretroviral therapy (cART) regimens might be an attractive therapeutic option for HIV type-1 (HIV-1)-infected patients; however, the pharmacokinetic profiles of such regimens are frequently unknown. Fourteen HIV-1-infected patients (age 21-55 years, 64% male) on stable cART with plasma HIV RNA
ISSN:	1359-6535 2040-2058
DOI:	10.3851/IMP1517