Donepezil Eliminates Suppressive Effects of b-Amyloid Peptide (1-42) on Long-Term Potentiation in the Hippocampus
b-Amyloid peptide 1-42 in a concentration of 200 nM impairs induction of long-term posttetanic potentiation of population spike in CA1 pyramidal neurons in rat hippocampal slices. Application of donepezil, a drug used for the treatment of Alzheimer disease, in a concentration of 1 kM eliminates the...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2010-07, Vol.149 (1), p.33-36 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Kapai, NA Solntseva, E I Skrebitskii, V G |
| description | b-Amyloid peptide 1-42 in a concentration of 200 nM impairs induction of long-term posttetanic potentiation of population spike in CA1 pyramidal neurons in rat hippocampal slices. Application of donepezil, a drug used for the treatment of Alzheimer disease, in a concentration of 1 kM eliminates the suppressive effect of b-amyloid peptide 1-42 on long-term posttenanic potentiation in the hippocampus. |
| doi_str_mv | 10.1007/s10517-010-0868-5 |
| format | Article |
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| ispartof | Bulletin of experimental biology and medicine, 2010-07, Vol.149 (1), p.33-36 |
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| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| title | Donepezil Eliminates Suppressive Effects of b-Amyloid Peptide (1-42) on Long-Term Potentiation in the Hippocampus |
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