Donepezil Eliminates Suppressive Effects of b-Amyloid Peptide (1-42) on Long-Term Potentiation in the Hippocampus

Donepezil Eliminates Suppressive Effects of b-Amyloid Peptide (1-42) on Long-Term Potentiation in the Hippocampus

b-Amyloid peptide 1-42 in a concentration of 200 nM impairs induction of long-term posttetanic potentiation of population spike in CA1 pyramidal neurons in rat hippocampal slices. Application of donepezil, a drug used for the treatment of Alzheimer disease, in a concentration of 1 kM eliminates the...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2010-07, Vol.149 (1), p.33-36
Hauptverfasser: Kapai, NA, Solntseva, E I, Skrebitskii, V G
Format: Artikel
Sprache:eng
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Zusammenfassung:b-Amyloid peptide 1-42 in a concentration of 200 nM impairs induction of long-term posttetanic potentiation of population spike in CA1 pyramidal neurons in rat hippocampal slices. Application of donepezil, a drug used for the treatment of Alzheimer disease, in a concentration of 1 kM eliminates the suppressive effect of b-amyloid peptide 1-42 on long-term posttenanic potentiation in the hippocampus.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-010-0868-5