Human herpes virus 6 infection is a hallmark of cord blood transplant in adults and may participate to delayed engraftment: a comparison with matched unrelated donors as stem cell source

Occurrence of CMV, EBV and human herpes virus 6 (HHV6) infections and immune reconstitution were compared in 15 adult patients receiving a cord blood transplantation (CBT) and 40 patients who received an allogeneic transplantation from a matched unrelated donor (MUD). Herpes virus DNA quantification...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2010-07, Vol.45 (7), p.1204-1211
Hauptverfasser:	Chevallier, P, Hebia-Fellah, I, Planche, L, Guillaume, T, Bressolette-Bodin, C, Coste-Burel, M, Rialland, F, Mohty, M, Imbert-Marcille, B-M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood cells Bone marrow Bone marrow, stem cells transplantation. Graft versus host reaction CD8 antigen Cell Biology Cord blood Cord Blood Stem Cell Transplantation - adverse effects Cytomegalovirus Cytomegalovirus Infections - etiology DNA viruses Epstein-Barr virus Epstein-Barr Virus Infections - etiology Female Graft Survival - immunology Health aspects Health risks Hematology Hematopoiesis - immunology Hematopoietic stem cells Herpes Herpes viruses Herpesvirus Herpesvirus 6, Human Herpesvirus diseases Human cytomegalovirus Human viral diseases Humans Immune reconstitution Immune response Incidence Infections Infectious diseases Internal Medicine Kinetics Leukocytes (neutrophilic) Lymphocytes Male Medical sciences Medicine Medicine & Public Health Middle Aged Mud Multivariate analysis Myeloablative Agonists - toxicity Natural killer cells Opportunistic Infections - etiology original-article Prevention Public Health Retrospective Studies Risk factors Roseolovirus Infections - etiology Stem cell transplantation Stem Cells Tissue Donors Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplants & implants Viral diseases Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye Viral Load Virus Activation - drug effects Viruses Young Adult
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Zusammenfassung:	Occurrence of CMV, EBV and human herpes virus 6 (HHV6) infections and immune reconstitution were compared in 15 adult patients receiving a cord blood transplantation (CBT) and 40 patients who received an allogeneic transplantation from a matched unrelated donor (MUD). Herpes virus DNA quantifications in the blood (459 samples) were performed before and then monthly up to 9 months after transplant and the main lymphocytes populations were counted at 3, 6 and 9 months. Incidence of HHV6 infection was significantly higher in the CBT group (80 vs 42.5%; P
ISSN:	0268-3369 1476-5365
DOI:	10.1038/bmt.2009.326