What is an immunological synapse?

Immunological synapses (IS) are emerging as highly organized 3D structures -formed by surface and cytoplasmic signalling and cytoskeletal molecules – that assemble at the zone of contact between a T cell and an antigen presenting cell (APC). The IS control functions that allow APC and T cells modula...

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Veröffentlicht in:	Microbes and infection 2010-06, Vol.12 (6), p.438-445
Hauptverfasser:	Rodríguez-Fernández, José Luis, Riol-Blanco, Lorena, Delgado-Martín, Cristina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen presenting cells Antigen-Presenting Cells - immunology Biological and medical sciences Cell Communication - immunology Cell–cell contact Cytoskeletal Proteins - immunology Dendritic cell Dendritic Cells - immunology Fundamental and applied biological sciences. Psychology Humans Immunological synapse Immunological Synapses - physiology Lymphocyte Microbiology Signal Transduction T-Lymphocytes - immunology
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Beschreibung
Zusammenfassung:	Immunological synapses (IS) are emerging as highly organized 3D structures -formed by surface and cytoplasmic signalling and cytoskeletal molecules – that assemble at the zone of contact between a T cell and an antigen presenting cell (APC). The IS control functions that allow APC and T cells modulate the immune response.
ISSN:	1286-4579 1769-714X
DOI:	10.1016/j.micinf.2010.03.003