Human mitochondrial mTERF wraps around DNA through a left-handed superhelical tandem repeat

The regulation of mitochondrial DNA (mtDNA) processes is slowly being characterized at a structural level. We present here crystal structures of human mitochondrial regulator mTERF, a transcription termination factor also implicated in replication pausing, in complex with double-stranded DNA oligonu...

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Veröffentlicht in:	Nature structural & molecular biology 2010-07, Vol.17 (7), p.891-893
Hauptverfasser:	Solà, Maria, Jacobs, Howard T, Rubio-Cosials, Anna, Bernadó, Pau, Fernández-Millán, Pablo, Jiménez-Menéndez, Nereida, Arnan, Carme, Coll, Miquel, Usón, Isabel, Montoya, Julio
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/726/2129 631/45/535 Basic-Leucine Zipper Transcription Factors - chemistry Basic-Leucine Zipper Transcription Factors - metabolism Binding sites Binding sites (Biochemistry) Biochemistry Biological Microscopy Biomedical and Life Sciences brief-communication Crystal structure DNA - chemistry DNA - metabolism DNA, Mitochondrial - chemistry DNA, Mitochondrial - metabolism Humans Life Sciences Membrane Biology Mitochondria - chemistry Mitochondria - metabolism Mitochondrial DNA Mitochondrial Proteins Models, Molecular Molecular biology Physiological aspects Protein Conformation Protein Structure Proteins Tandem Repeat Sequences Transcription factors
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Beschreibung
Zusammenfassung:	The regulation of mitochondrial DNA (mtDNA) processes is slowly being characterized at a structural level. We present here crystal structures of human mitochondrial regulator mTERF, a transcription termination factor also implicated in replication pausing, in complex with double-stranded DNA oligonucleotides containing the tRNALeuUUR gene sequence. mTERF comprises nine left-handed helical tandem repeats that form a left-handed superhelix, the Zurdo domain.
ISSN:	1545-9993 1545-9985
DOI:	10.1038/nsmb.1859