A Proposed Comprehensive Pathophysiology of Thrombotic Thrombocytopenic Purpura With Implicit Novel Tests and Therapies

The first detailed comprehensive hypothesis for the pathophysiology of TTP is proposed which accounts for all of the features of TTP at several levels of reference: clinical, physiologic, biochemical, hematologic, and tissue pathology. From the proposed pathophysiology, by deduction, a number of nov...

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Veröffentlicht in:	Seminars in thrombosis and hemostasis 1980, Vol.6 (4), p.356-390
Hauptverfasser:	Nalbandian, Robert M., Henry, Raymond L.
Format:	Artikel
Sprache:	eng
Schlagworte:	beta-Thromboglobulin Blood Transfusion Endothelium - physiopathology Exchange Transfusion, Whole Blood Fibronectins Hemolytic-Uremic Syndrome - diagnosis Heparin - therapeutic use Humans Macromolecular Substances Mononuclear Phagocyte System - physiopathology Plasma - transplantation Plasminogen Activators Platelet Aggregation - drug effects Prostaglandin-Endoperoxide Synthases - metabolism Prostaglandins - metabolism Proteoglycans Purpura, Thrombotic Thrombocytopenic - diagnosis Purpura, Thrombotic Thrombocytopenic - physiopathology Purpura, Thrombotic Thrombocytopenic - therapy Steroids - therapeutic use Vitamin E - therapeutic use
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Zusammenfassung:	The first detailed comprehensive hypothesis for the pathophysiology of TTP is proposed which accounts for all of the features of TTP at several levels of reference: clinical, physiologic, biochemical, hematologic, and tissue pathology. From the proposed pathophysiology, by deduction, a number of novel diagnostic tests and several rational, promising therapeutic modalities.
ISSN:	0094-6176 1098-9064
DOI:	10.1055/s-2007-1005109