Human IgE antibody serology: A primer for the practicing North American allergist/immunologist

The allergist/immunologist judiciously diagnoses allergic disease by using confirmatory IgE antibody data from in vivo and in vitro assays after the collection of a clinical history. After an overview of historical events, clinically available allergen-specific IgE assays from Phadia, Siemens, and H...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2010-07, Vol.126 (1), p.33-38
Hauptverfasser:	Hamilton, Robert G., PhD, DABMLI, Williams, P. Brock, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	affinity Allergens - immunology Allergies Allergy Allergy and Immunology Antibodies, Anti-Idiotypic - therapeutic use Biological and medical sciences clonality concentration Fundamental and applied biological sciences. Psychology Fundamental immunology human Humans IgE Immunity, Humoral Immunoglobulin E - blood Immunopathology Laboratories Market entry Medical sciences Point-of-Care Systems Radioallergosorbent Test Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis specific activity specific IgE to total IgE ratio
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Beschreibung
Zusammenfassung:	The allergist/immunologist judiciously diagnoses allergic disease by using confirmatory IgE antibody data from in vivo and in vitro assays after the collection of a clinical history. After an overview of historical events, clinically available allergen-specific IgE assays from Phadia, Siemens, and Hycor are contrasted by their design and performance characteristics. The assays share comparable working ranges, analytical sensitivities, and excellent precision, reproducibility, and linearity to a performance standard of
ISSN:	0091-6749 1097-6825
DOI:	10.1016/j.jaci.2010.03.014