A facile construction of the tricyclic 5-7-6 scaffold of fungi-derived diterpenoids. The first total synthesis of (±)-heptemerone G and a new approach to Danishefsky’s intermediate for a guanacastepene A synthesis

A facile construction of the tricyclic 5-7-6 scaffold of fungi-derived diterpenoids. The first total synthesis of (±)-heptemerone G and a new approach to Danishefsky’s intermediate for a guanacastepene A synthesis

The first total synthesis of (±)-heptemerone G, a diterpenoid metabolite of a submerged culture Coprinus heptemerus, and a new approach to an advanced intermediate for a synthesis of guanacastepene A are reported.

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Veröffentlicht in:Tetrahedron letters 2010-08, Vol.51 (33), p.4344-4346
Hauptverfasser: Michalak, Karol, Michalak, Michał, Wicha, Jerzy
Format: Artikel
Sprache:eng
Schlagworte:
Annulation reactions
Construction
Coprinus
Culture
Medium-ring compounds
Metabolites
Quaternary stereocenters
Scaffolds
Submerged
Synthesis (chemistry)
Terpenoids
Tetrahedrons
Total synthesis
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Zusammenfassung:The first total synthesis of (±)-heptemerone G, a diterpenoid metabolite of a submerged culture Coprinus heptemerus, and a new approach to an advanced intermediate for a synthesis of guanacastepene A are reported.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2010.06.064