Localized magnetic-loop induction hyperthermia of the rabbit brain

The Magnetrode magnetic‐loop applicator has been used for deep internal hyperthermia with minimal toxicity and without normal tissue injury. Until now, the effects of localized radiofrequency hyperthermia on the brain have not been adequately studied because of the potential hazards involved in trying to effect brain heating while preserving overlaying surface tissues. We found that normal rabbit brain could be heated to potentially tumoricidal temperatures (42–43°C) without apparent histopathologic or clinical damage to brain, skull, external eye, subcutaneous tissue, or skin.