4-acetylantroquinonol B isolated from mycelium of Antrodia cinnamomea inhibits proliferation of hepatoma cells
BACKGROUND: Antrodia cinnamomea is known for its antihepatoma activity, yet the identity of its active compound was unclear. In this study, a 5-ton fermenter was used to prepare sufficient mycelium of A. cinnamomea for active compound isolation and identification.RESULTS: Using antiproliferative act...
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| Veröffentlicht in: | Journal of the science of food and agriculture 2010-08, Vol.90 (10), p.1739-1744 |
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| creator | Lin, Yu-Wei Pan, Jih-Hung Liu, Rui Hai Kuo, Yueh-Hsiung Sheen, Lee-Yen Chiang, Been-Huang |
| description | BACKGROUND: Antrodia cinnamomea is known for its antihepatoma activity, yet the identity of its active compound was unclear. In this study, a 5-ton fermenter was used to prepare sufficient mycelium of A. cinnamomea for active compound isolation and identification.RESULTS: Using antiproliferative activity toward HepG2 cells as guidance in the isolation process, 4-acetylantroquinonol B was purified and identified to be the major bioactive compound of A. cinnamomea cultivated by submerged fermentation. The median effective doses (EC₅₀) of 4-acetylantroquinonol B for HepG2 cells were 0.10 ± 0.00 and 0.08 ± 0.00 μg mL⁻¹ for 72 and 96 h treatments, respectively. The selective indices of 4-acetylantroquinonol B were 100 and 125 for 72 and 96 h treatments, respectively, indicating that this compound had high selective activity for hepatoma cells.CONCLUSION: 4-Acetylantroquinonol B is the major antihepatoma constituent of Antrodia cinnamomea mycelium produced by submerged fermentation. Copyright |
| doi_str_mv | 10.1002/jsfa.4010 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_754562109</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2068878721</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4750-676c3570b2e1975c5e0430e79016876e3f5dc0b67349d97684f93ce8ec08d7ef3</originalsourceid><addsrcrecordid>eNqF0Utv1DAQAOAIgehSOPAHIEJCiEPa8Ts5Li1bQFU5LAWJi-V1bOolsRc7Eey_xyFLkZAQJ1vyN-N5FMVjBCcIAJ9uk1UnFBDcKRYIGlFBvt8tFvkNVwxRfFQ8SGkLAE3D-f3iCAPjlBKxKDytlDbDvlN-iOHb6HzwoStflS6FTg2mLW0Mfdnvtenc2JfBlstJtk6V2nmv-tAbVTp_4zZuSOUuhs5ZE9Xggp_0jdmpIfRZm65LD4t7VnXJPDqcx8X16vWHszfV5fuLt2fLy0pTwaDigmvCBGywQY1gmhmgBIxoAPFacEMsazVsuCC0aRvBa2obok1tNNStMJYcFy_mvLupKZMG2bs0VaC8CWOSglHGcZ7V_yUhFDj8ks_-ktswRp_bkAwL3vAa0YxezkjHkFI0Vu6i61XcSwRyWpacliWnZWX75JBw3PSmvZW_t5PB8wNQSavORuW1S38cbjDBwLM7nd1315n9v3-U79ar5eHrao5waTA_biNU_CrzUAWTn64u5NVanK8_rj7L8-yfzt6qINWXmKu4XmNABFDNAVMgPwG7GcN4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>527696814</pqid></control><display><type>article</type><title>4-acetylantroquinonol B isolated from mycelium of Antrodia cinnamomea inhibits proliferation of hepatoma cells</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><creator>Lin, Yu-Wei ; Pan, Jih-Hung ; Liu, Rui Hai ; Kuo, Yueh-Hsiung ; Sheen, Lee-Yen ; Chiang, Been-Huang</creator><creatorcontrib>Lin, Yu-Wei ; Pan, Jih-Hung ; Liu, Rui Hai ; Kuo, Yueh-Hsiung ; Sheen, Lee-Yen ; Chiang, Been-Huang</creatorcontrib><description>BACKGROUND: Antrodia cinnamomea is known for its antihepatoma activity, yet the identity of its active compound was unclear. In this study, a 5-ton fermenter was used to prepare sufficient mycelium of A. cinnamomea for active compound isolation and identification.RESULTS: Using antiproliferative activity toward HepG2 cells as guidance in the isolation process, 4-acetylantroquinonol B was purified and identified to be the major bioactive compound of A. cinnamomea cultivated by submerged fermentation. The median effective doses (EC₅₀) of 4-acetylantroquinonol B for HepG2 cells were 0.10 ± 0.00 and 0.08 ± 0.00 μg mL⁻¹ for 72 and 96 h treatments, respectively. The selective indices of 4-acetylantroquinonol B were 100 and 125 for 72 and 96 h treatments, respectively, indicating that this compound had high selective activity for hepatoma cells.CONCLUSION: 4-Acetylantroquinonol B is the major antihepatoma constituent of Antrodia cinnamomea mycelium produced by submerged fermentation. Copyright</description><identifier>ISSN: 0022-5142</identifier><identifier>EISSN: 1097-0010</identifier><identifier>DOI: 10.1002/jsfa.4010</identifier><identifier>PMID: 20564437</identifier><identifier>CODEN: JSFAAE</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>4-acetylantroquinonol B ; 4-Butyrolactone - analogs & derivatives ; 4-Butyrolactone - isolation & purification ; 4-Butyrolactone - pharmacology ; 4-Butyrolactone - therapeutic use ; anticarcinogenic activity ; Antineoplastic Agents - pharmacology ; Antineoplastic Agents - therapeutic use ; antiproliferation ; antiproliferative activity ; Antrodia - chemistry ; Antrodia cinnamomea ; Biological and medical sciences ; Biological Products - pharmacology ; Biological Products - therapeutic use ; Carcinoma, Hepatocellular - drug therapy ; cell proliferation ; Cell Proliferation - drug effects ; Cells ; Chemical compounds ; Cyclohexanones - isolation & purification ; Cyclohexanones - pharmacology ; Cyclohexanones - therapeutic use ; edible fungi ; Fermentation ; Food industries ; Food science ; functional foods ; Fundamental and applied biological sciences. Psychology ; Fungi ; Hep G2 Cells ; hepatoma ; hepatoma cells ; hepatoprotective effect ; Humans ; inhibitors ; isolation ; Liver diseases ; Liver Neoplasms - drug therapy ; Mycelium ; submerged fermentation</subject><ispartof>Journal of the science of food and agriculture, 2010-08, Vol.90 (10), p.1739-1744</ispartof><rights>Copyright © 2010 Society of Chemical Industry</rights><rights>2015 INIST-CNRS</rights><rights>Copyright (c) 2010 Society of Chemical Industry.</rights><rights>Copyright John Wiley and Sons, Limited Aug 15, 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4750-676c3570b2e1975c5e0430e79016876e3f5dc0b67349d97684f93ce8ec08d7ef3</citedby><cites>FETCH-LOGICAL-c4750-676c3570b2e1975c5e0430e79016876e3f5dc0b67349d97684f93ce8ec08d7ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjsfa.4010$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjsfa.4010$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22923206$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20564437$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Yu-Wei</creatorcontrib><creatorcontrib>Pan, Jih-Hung</creatorcontrib><creatorcontrib>Liu, Rui Hai</creatorcontrib><creatorcontrib>Kuo, Yueh-Hsiung</creatorcontrib><creatorcontrib>Sheen, Lee-Yen</creatorcontrib><creatorcontrib>Chiang, Been-Huang</creatorcontrib><title>4-acetylantroquinonol B isolated from mycelium of Antrodia cinnamomea inhibits proliferation of hepatoma cells</title><title>Journal of the science of food and agriculture</title><addtitle>J. Sci. Food Agric</addtitle><description>BACKGROUND: Antrodia cinnamomea is known for its antihepatoma activity, yet the identity of its active compound was unclear. In this study, a 5-ton fermenter was used to prepare sufficient mycelium of A. cinnamomea for active compound isolation and identification.RESULTS: Using antiproliferative activity toward HepG2 cells as guidance in the isolation process, 4-acetylantroquinonol B was purified and identified to be the major bioactive compound of A. cinnamomea cultivated by submerged fermentation. The median effective doses (EC₅₀) of 4-acetylantroquinonol B for HepG2 cells were 0.10 ± 0.00 and 0.08 ± 0.00 μg mL⁻¹ for 72 and 96 h treatments, respectively. The selective indices of 4-acetylantroquinonol B were 100 and 125 for 72 and 96 h treatments, respectively, indicating that this compound had high selective activity for hepatoma cells.CONCLUSION: 4-Acetylantroquinonol B is the major antihepatoma constituent of Antrodia cinnamomea mycelium produced by submerged fermentation. Copyright</description><subject>4-acetylantroquinonol B</subject><subject>4-Butyrolactone - analogs & derivatives</subject><subject>4-Butyrolactone - isolation & purification</subject><subject>4-Butyrolactone - pharmacology</subject><subject>4-Butyrolactone - therapeutic use</subject><subject>anticarcinogenic activity</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>antiproliferation</subject><subject>antiproliferative activity</subject><subject>Antrodia - chemistry</subject><subject>Antrodia cinnamomea</subject><subject>Biological and medical sciences</subject><subject>Biological Products - pharmacology</subject><subject>Biological Products - therapeutic use</subject><subject>Carcinoma, Hepatocellular - drug therapy</subject><subject>cell proliferation</subject><subject>Cell Proliferation - drug effects</subject><subject>Cells</subject><subject>Chemical compounds</subject><subject>Cyclohexanones - isolation & purification</subject><subject>Cyclohexanones - pharmacology</subject><subject>Cyclohexanones - therapeutic use</subject><subject>edible fungi</subject><subject>Fermentation</subject><subject>Food industries</subject><subject>Food science</subject><subject>functional foods</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fungi</subject><subject>Hep G2 Cells</subject><subject>hepatoma</subject><subject>hepatoma cells</subject><subject>hepatoprotective effect</subject><subject>Humans</subject><subject>inhibitors</subject><subject>isolation</subject><subject>Liver diseases</subject><subject>Liver Neoplasms - drug therapy</subject><subject>Mycelium</subject><subject>submerged fermentation</subject><issn>0022-5142</issn><issn>1097-0010</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0Utv1DAQAOAIgehSOPAHIEJCiEPa8Ts5Li1bQFU5LAWJi-V1bOolsRc7Eey_xyFLkZAQJ1vyN-N5FMVjBCcIAJ9uk1UnFBDcKRYIGlFBvt8tFvkNVwxRfFQ8SGkLAE3D-f3iCAPjlBKxKDytlDbDvlN-iOHb6HzwoStflS6FTg2mLW0Mfdnvtenc2JfBlstJtk6V2nmv-tAbVTp_4zZuSOUuhs5ZE9Xggp_0jdmpIfRZm65LD4t7VnXJPDqcx8X16vWHszfV5fuLt2fLy0pTwaDigmvCBGywQY1gmhmgBIxoAPFacEMsazVsuCC0aRvBa2obok1tNNStMJYcFy_mvLupKZMG2bs0VaC8CWOSglHGcZ7V_yUhFDj8ks_-ktswRp_bkAwL3vAa0YxezkjHkFI0Vu6i61XcSwRyWpacliWnZWX75JBw3PSmvZW_t5PB8wNQSavORuW1S38cbjDBwLM7nd1315n9v3-U79ar5eHrao5waTA_biNU_CrzUAWTn64u5NVanK8_rj7L8-yfzt6qINWXmKu4XmNABFDNAVMgPwG7GcN4</recordid><startdate>20100815</startdate><enddate>20100815</enddate><creator>Lin, Yu-Wei</creator><creator>Pan, Jih-Hung</creator><creator>Liu, Rui Hai</creator><creator>Kuo, Yueh-Hsiung</creator><creator>Sheen, Lee-Yen</creator><creator>Chiang, Been-Huang</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><general>John Wiley and Sons, Limited</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QL</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7ST</scope><scope>7T5</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>SOI</scope><scope>7X8</scope><scope>7QO</scope></search><sort><creationdate>20100815</creationdate><title>4-acetylantroquinonol B isolated from mycelium of Antrodia cinnamomea inhibits proliferation of hepatoma cells</title><author>Lin, Yu-Wei ; Pan, Jih-Hung ; Liu, Rui Hai ; Kuo, Yueh-Hsiung ; Sheen, Lee-Yen ; Chiang, Been-Huang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4750-676c3570b2e1975c5e0430e79016876e3f5dc0b67349d97684f93ce8ec08d7ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>4-acetylantroquinonol B</topic><topic>4-Butyrolactone - analogs & derivatives</topic><topic>4-Butyrolactone - isolation & purification</topic><topic>4-Butyrolactone - pharmacology</topic><topic>4-Butyrolactone - therapeutic use</topic><topic>anticarcinogenic activity</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>antiproliferation</topic><topic>antiproliferative activity</topic><topic>Antrodia - chemistry</topic><topic>Antrodia cinnamomea</topic><topic>Biological and medical sciences</topic><topic>Biological Products - pharmacology</topic><topic>Biological Products - therapeutic use</topic><topic>Carcinoma, Hepatocellular - drug therapy</topic><topic>cell proliferation</topic><topic>Cell Proliferation - drug effects</topic><topic>Cells</topic><topic>Chemical compounds</topic><topic>Cyclohexanones - isolation & purification</topic><topic>Cyclohexanones - pharmacology</topic><topic>Cyclohexanones - therapeutic use</topic><topic>edible fungi</topic><topic>Fermentation</topic><topic>Food industries</topic><topic>Food science</topic><topic>functional foods</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fungi</topic><topic>Hep G2 Cells</topic><topic>hepatoma</topic><topic>hepatoma cells</topic><topic>hepatoprotective effect</topic><topic>Humans</topic><topic>inhibitors</topic><topic>isolation</topic><topic>Liver diseases</topic><topic>Liver Neoplasms - drug therapy</topic><topic>Mycelium</topic><topic>submerged fermentation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Yu-Wei</creatorcontrib><creatorcontrib>Pan, Jih-Hung</creatorcontrib><creatorcontrib>Liu, Rui Hai</creatorcontrib><creatorcontrib>Kuo, Yueh-Hsiung</creatorcontrib><creatorcontrib>Sheen, Lee-Yen</creatorcontrib><creatorcontrib>Chiang, Been-Huang</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>Journal of the science of food and agriculture</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Yu-Wei</au><au>Pan, Jih-Hung</au><au>Liu, Rui Hai</au><au>Kuo, Yueh-Hsiung</au><au>Sheen, Lee-Yen</au><au>Chiang, Been-Huang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>4-acetylantroquinonol B isolated from mycelium of Antrodia cinnamomea inhibits proliferation of hepatoma cells</atitle><jtitle>Journal of the science of food and agriculture</jtitle><addtitle>J. Sci. Food Agric</addtitle><date>2010-08-15</date><risdate>2010</risdate><volume>90</volume><issue>10</issue><spage>1739</spage><epage>1744</epage><pages>1739-1744</pages><issn>0022-5142</issn><eissn>1097-0010</eissn><coden>JSFAAE</coden><abstract>BACKGROUND: Antrodia cinnamomea is known for its antihepatoma activity, yet the identity of its active compound was unclear. In this study, a 5-ton fermenter was used to prepare sufficient mycelium of A. cinnamomea for active compound isolation and identification.RESULTS: Using antiproliferative activity toward HepG2 cells as guidance in the isolation process, 4-acetylantroquinonol B was purified and identified to be the major bioactive compound of A. cinnamomea cultivated by submerged fermentation. The median effective doses (EC₅₀) of 4-acetylantroquinonol B for HepG2 cells were 0.10 ± 0.00 and 0.08 ± 0.00 μg mL⁻¹ for 72 and 96 h treatments, respectively. The selective indices of 4-acetylantroquinonol B were 100 and 125 for 72 and 96 h treatments, respectively, indicating that this compound had high selective activity for hepatoma cells.CONCLUSION: 4-Acetylantroquinonol B is the major antihepatoma constituent of Antrodia cinnamomea mycelium produced by submerged fermentation. Copyright</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>20564437</pmid><doi>10.1002/jsfa.4010</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of the science of food and agriculture, 2010-08, Vol.90 (10), p.1739-1744 |
| issn | 0022-5142 1097-0010 |
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| subjects | 4-acetylantroquinonol B 4-Butyrolactone - analogs & derivatives 4-Butyrolactone - isolation & purification 4-Butyrolactone - pharmacology 4-Butyrolactone - therapeutic use anticarcinogenic activity Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use antiproliferation antiproliferative activity Antrodia - chemistry Antrodia cinnamomea Biological and medical sciences Biological Products - pharmacology Biological Products - therapeutic use Carcinoma, Hepatocellular - drug therapy cell proliferation Cell Proliferation - drug effects Cells Chemical compounds Cyclohexanones - isolation & purification Cyclohexanones - pharmacology Cyclohexanones - therapeutic use edible fungi Fermentation Food industries Food science functional foods Fundamental and applied biological sciences. Psychology Fungi Hep G2 Cells hepatoma hepatoma cells hepatoprotective effect Humans inhibitors isolation Liver diseases Liver Neoplasms - drug therapy Mycelium submerged fermentation |
| title | 4-acetylantroquinonol B isolated from mycelium of Antrodia cinnamomea inhibits proliferation of hepatoma cells |
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