pattern of linkage disequilibrium in German Holstein cattle

pattern of linkage disequilibrium in German Holstein cattle

This study presents a second generation of linkage disequilibrium (LD) map statistics for the whole genome of the Holstein-Friesian population, which has a four times higher resolution compared with that of the maps available so far. We used DNA samples of 810 German Holstein-Friesian cattle genotyp...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Animal genetics 2010-08, Vol.41 (4), p.346-356
Hauptverfasser: Qanbari, S, Pimentel, E.C.G, Tetens, J, Thaller, G, Lichtner, P, Sharifi, A.R, Simianer, H
Format: Artikel
Sprache:eng
Schlagworte:
Alleles
Animals
bovine genome
Cattle - genetics
Disequilibrium
effective population size
Genetic Variation
Genetics, Population
Genome-Wide Association Study
Genomes
haplo-block structure
Haplotypes
Linkage Disequilibrium
Polymorphism
Polymorphism, Single Nucleotide
Population
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:This study presents a second generation of linkage disequilibrium (LD) map statistics for the whole genome of the Holstein-Friesian population, which has a four times higher resolution compared with that of the maps available so far. We used DNA samples of 810 German Holstein-Friesian cattle genotyped by the Illumina Bovine SNP50K BeadChip to analyse LD structure. A panel of 40 854 (75.6%) markers was included in the final analysis. The pairwise r² statistic of SNPs up to 5 Mb apart across the genome was estimated. A mean value of r² = 0.30 ± 0.32 was observed in pairwise distances of
ISSN:0268-9146
1365-2052
DOI:10.1111/j.1365-2052.2009.02011.x