1H-MRSI pattern perturbation in a mouse glioma: the effects of acute hyperglycemia and moderate hypothermia

1H-MRSI pattern perturbation in a mouse glioma: the effects of acute hyperglycemia and moderate hypothermia

MR spectroscopic Imaging (MRSI), with PRESS localization, is used here to monitor the effects of acute hyperglycemia in the spectral pattern of 11 mice bearing GL261 gliomas at normothermia (36.5–37.5°C) and at hypothermia (28.5–29.5°C). These in vivo studies were complemented by ex vivo high resolu...

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Veröffentlicht in:NMR in biomedicine 2010-01, Vol.23 (1), p.23-33
Hauptverfasser: Simões, R.V., Delgado-Goñi, T., Lope-Piedrafita, S., Arús, C.
Format: Artikel
Sprache:eng
Schlagworte:
acute hyperglycemia
Animals
Blood Glucose - metabolism
Body Temperature
brain tumor
Disease Models, Animal
Female
GL261 cells
Glioma - metabolism
Glioma - pathology
Glioma - physiopathology
Humans
Hyperglycemia - metabolism
Hypothermia - metabolism
Magnetic Resonance Spectroscopy - methods
Mice
Mice, Inbred C57BL
moderate hypothermia
MRS pattern
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Zusammenfassung:MR spectroscopic Imaging (MRSI), with PRESS localization, is used here to monitor the effects of acute hyperglycemia in the spectral pattern of 11 mice bearing GL261 gliomas at normothermia (36.5–37.5°C) and at hypothermia (28.5–29.5°C). These in vivo studies were complemented by ex vivo high resolution magic angle spinning (HR‐MAS) analysis of GL261 tumor samples from 6 animals sacrificed by focused microwave irradiation, and blood glucose measurements in 12 control mice. Apparent glucose levels, monitored by in vivo MRSI in brain tumors during acute hyperglycemia, rose to an average of 1.6‐fold during hypothermia (p 
ISSN:0952-3480
1099-1492
DOI:10.1002/nbm.1421