Bestrophin 2: An anion channel associated with neurogenesis in chemosensory systems
The chemosensory neuroepithelia of the vertebrate olfactory system share a life‐long ability to regenerate. Novel neurons proliferate from basal stem cells that continuously replace old or damaged sensory neurons. The sensory neurons of the mouse and rat olfactory system specifically express bestrop...
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| Veröffentlicht in: | Journal of comparative neurology (1911) 2009-08, Vol.515 (5), p.585-599 |
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| container_title | Journal of comparative neurology (1911) |
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| creator | Klimmeck, Daniel Daiber, Philipp C. Brühl, Anja Baumann, Arnd Frings, Stephan Möhrlen, Frank |
| description | The chemosensory neuroepithelia of the vertebrate olfactory system share a life‐long ability to regenerate. Novel neurons proliferate from basal stem cells that continuously replace old or damaged sensory neurons. The sensory neurons of the mouse and rat olfactory system specifically express bestrophin 2, a member of the bestrophin family of calcium‐activated chloride channels. This channel was recently proposed to operate as a transduction channel in olfactory sensory cilia. We raised a polyclonal antibody against bestrophin 2 and characterized the expression pattern of this protein in the mouse main olfactory epithelium, septal organ of Masera, and vomeronasal organ. Comparison with the maturation markers growth‐associated protein 43 and olfactory marker protein revealed that bestrophin 2 was expressed in developing sensory neurons of all chemosensory neuroepithelia, but was restricted to proximal cilia in mature sensory neurons. Our results suggest that bestrophin 2 plays a critical role during differentiation and growth of axons and cilia. In mature olfactory receptor neurons, it appears to support growth and function of sensory cilia. J. Comp. Neurol. 515:585–599, 2009. © 2009 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/cne.22075 |
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Novel neurons proliferate from basal stem cells that continuously replace old or damaged sensory neurons. The sensory neurons of the mouse and rat olfactory system specifically express bestrophin 2, a member of the bestrophin family of calcium‐activated chloride channels. This channel was recently proposed to operate as a transduction channel in olfactory sensory cilia. We raised a polyclonal antibody against bestrophin 2 and characterized the expression pattern of this protein in the mouse main olfactory epithelium, septal organ of Masera, and vomeronasal organ. Comparison with the maturation markers growth‐associated protein 43 and olfactory marker protein revealed that bestrophin 2 was expressed in developing sensory neurons of all chemosensory neuroepithelia, but was restricted to proximal cilia in mature sensory neurons. Our results suggest that bestrophin 2 plays a critical role during differentiation and growth of axons and cilia. In mature olfactory receptor neurons, it appears to support growth and function of sensory cilia. J. Comp. Neurol. 515:585–599, 2009. © 2009 Wiley‐Liss, Inc.</description><identifier>ISSN: 0021-9967</identifier><identifier>EISSN: 1096-9861</identifier><identifier>DOI: 10.1002/cne.22075</identifier><identifier>PMID: 19480000</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Axons - physiology ; Bestrophins ; calcium activated chloride channels ; Chloride Channels - genetics ; Chloride Channels - metabolism ; Cilia - physiology ; Eye Proteins - genetics ; Eye Proteins - metabolism ; Humans ; Mice ; Neurogenesis - physiology ; neuronal maturation ; Olfactory Bulb - cytology ; Olfactory Bulb - metabolism ; olfactory epithelia ; Olfactory Marker Protein - genetics ; Olfactory Marker Protein - metabolism ; Olfactory Mucosa - cytology ; Olfactory Mucosa - physiology ; Olfactory Perception - physiology ; Olfactory Receptor Neurons - cytology ; Olfactory Receptor Neurons - metabolism ; Rats ; Rats, Wistar ; Recombinant Fusion Proteins - genetics ; Recombinant Fusion Proteins - metabolism ; regeneration ; Vomeronasal Organ - cytology ; Vomeronasal Organ - physiology</subject><ispartof>Journal of comparative neurology (1911), 2009-08, Vol.515 (5), p.585-599</ispartof><rights>Copyright © 2009 Wiley‐Liss, Inc.</rights><rights>Copyright 2009 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4185-bd82690db9710645bb858fd4cb3d048b01d5284fb5800647e4f7dc5088982e63</citedby><cites>FETCH-LOGICAL-c4185-bd82690db9710645bb858fd4cb3d048b01d5284fb5800647e4f7dc5088982e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcne.22075$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcne.22075$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19480000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klimmeck, Daniel</creatorcontrib><creatorcontrib>Daiber, Philipp C.</creatorcontrib><creatorcontrib>Brühl, Anja</creatorcontrib><creatorcontrib>Baumann, Arnd</creatorcontrib><creatorcontrib>Frings, Stephan</creatorcontrib><creatorcontrib>Möhrlen, Frank</creatorcontrib><title>Bestrophin 2: An anion channel associated with neurogenesis in chemosensory systems</title><title>Journal of comparative neurology (1911)</title><addtitle>J. Comp. Neurol</addtitle><description>The chemosensory neuroepithelia of the vertebrate olfactory system share a life‐long ability to regenerate. Novel neurons proliferate from basal stem cells that continuously replace old or damaged sensory neurons. The sensory neurons of the mouse and rat olfactory system specifically express bestrophin 2, a member of the bestrophin family of calcium‐activated chloride channels. This channel was recently proposed to operate as a transduction channel in olfactory sensory cilia. We raised a polyclonal antibody against bestrophin 2 and characterized the expression pattern of this protein in the mouse main olfactory epithelium, septal organ of Masera, and vomeronasal organ. Comparison with the maturation markers growth‐associated protein 43 and olfactory marker protein revealed that bestrophin 2 was expressed in developing sensory neurons of all chemosensory neuroepithelia, but was restricted to proximal cilia in mature sensory neurons. Our results suggest that bestrophin 2 plays a critical role during differentiation and growth of axons and cilia. In mature olfactory receptor neurons, it appears to support growth and function of sensory cilia. J. Comp. Neurol. 515:585–599, 2009. © 2009 Wiley‐Liss, Inc.</description><subject>Animals</subject><subject>Axons - physiology</subject><subject>Bestrophins</subject><subject>calcium activated chloride channels</subject><subject>Chloride Channels - genetics</subject><subject>Chloride Channels - metabolism</subject><subject>Cilia - physiology</subject><subject>Eye Proteins - genetics</subject><subject>Eye Proteins - metabolism</subject><subject>Humans</subject><subject>Mice</subject><subject>Neurogenesis - physiology</subject><subject>neuronal maturation</subject><subject>Olfactory Bulb - cytology</subject><subject>Olfactory Bulb - metabolism</subject><subject>olfactory epithelia</subject><subject>Olfactory Marker Protein - genetics</subject><subject>Olfactory Marker Protein - metabolism</subject><subject>Olfactory Mucosa - cytology</subject><subject>Olfactory Mucosa - physiology</subject><subject>Olfactory Perception - physiology</subject><subject>Olfactory Receptor Neurons - cytology</subject><subject>Olfactory Receptor Neurons - metabolism</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Recombinant Fusion Proteins - genetics</subject><subject>Recombinant Fusion Proteins - metabolism</subject><subject>regeneration</subject><subject>Vomeronasal Organ - cytology</subject><subject>Vomeronasal Organ - physiology</subject><issn>0021-9967</issn><issn>1096-9861</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1PGzEQhq0KVELaQ_8A8omqhwV71_ba3GgEARWllUDq0dqP2cawawdPIpp_j0MCnNrTaDTPvJp5CPnC2QlnLD9tPJzkOSvlBzLizKjMaMX3yCjNeGaMKg_IIeI9Y8yYQn8kB9wInTo2IrffAZcxLObO0_yMnntaeRc8beaV99DTCjE0rlpCS5_cck49rGL4Ax7QIXUbDoaA4DHENcU1LmHAT2S_q3qEz7s6JneXF3eTq-zm5_R6cn6TNYJrmdWtzpVhbW1KzpSQda2l7lrR1EXLhK4Zb2WuRVfLdKsSJYiubBvJtDY6B1WMyddt7CKGx1V6ww4OG-j7ykNYoS2lkJIzrhN5_F9SlYUyWpoEftuCTQyIETq7iG6o4tpyZjeqbVJtX1Qn9mgXuqoHaN_JndsEnG6BJ9fD-t9JdjK7eI3Mthsuefz7tlHFh82Jifw9m9rk5Ed--cvYWfEM7LqWQw</recordid><startdate>20090810</startdate><enddate>20090810</enddate><creator>Klimmeck, Daniel</creator><creator>Daiber, Philipp C.</creator><creator>Brühl, Anja</creator><creator>Baumann, Arnd</creator><creator>Frings, Stephan</creator><creator>Möhrlen, Frank</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20090810</creationdate><title>Bestrophin 2: An anion channel associated with neurogenesis in chemosensory systems</title><author>Klimmeck, Daniel ; Daiber, Philipp C. ; Brühl, Anja ; Baumann, Arnd ; Frings, Stephan ; Möhrlen, Frank</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4185-bd82690db9710645bb858fd4cb3d048b01d5284fb5800647e4f7dc5088982e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Animals</topic><topic>Axons - physiology</topic><topic>Bestrophins</topic><topic>calcium activated chloride channels</topic><topic>Chloride Channels - genetics</topic><topic>Chloride Channels - metabolism</topic><topic>Cilia - physiology</topic><topic>Eye Proteins - genetics</topic><topic>Eye Proteins - metabolism</topic><topic>Humans</topic><topic>Mice</topic><topic>Neurogenesis - physiology</topic><topic>neuronal maturation</topic><topic>Olfactory Bulb - cytology</topic><topic>Olfactory Bulb - metabolism</topic><topic>olfactory epithelia</topic><topic>Olfactory Marker Protein - genetics</topic><topic>Olfactory Marker Protein - metabolism</topic><topic>Olfactory Mucosa - cytology</topic><topic>Olfactory Mucosa - physiology</topic><topic>Olfactory Perception - physiology</topic><topic>Olfactory Receptor Neurons - cytology</topic><topic>Olfactory Receptor Neurons - metabolism</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Recombinant Fusion Proteins - genetics</topic><topic>Recombinant Fusion Proteins - metabolism</topic><topic>regeneration</topic><topic>Vomeronasal Organ - cytology</topic><topic>Vomeronasal Organ - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klimmeck, Daniel</creatorcontrib><creatorcontrib>Daiber, Philipp C.</creatorcontrib><creatorcontrib>Brühl, Anja</creatorcontrib><creatorcontrib>Baumann, Arnd</creatorcontrib><creatorcontrib>Frings, Stephan</creatorcontrib><creatorcontrib>Möhrlen, Frank</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of comparative neurology (1911)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klimmeck, Daniel</au><au>Daiber, Philipp C.</au><au>Brühl, Anja</au><au>Baumann, Arnd</au><au>Frings, Stephan</au><au>Möhrlen, Frank</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bestrophin 2: An anion channel associated with neurogenesis in chemosensory systems</atitle><jtitle>Journal of comparative neurology (1911)</jtitle><addtitle>J. Comp. Neurol</addtitle><date>2009-08-10</date><risdate>2009</risdate><volume>515</volume><issue>5</issue><spage>585</spage><epage>599</epage><pages>585-599</pages><issn>0021-9967</issn><eissn>1096-9861</eissn><abstract>The chemosensory neuroepithelia of the vertebrate olfactory system share a life‐long ability to regenerate. Novel neurons proliferate from basal stem cells that continuously replace old or damaged sensory neurons. The sensory neurons of the mouse and rat olfactory system specifically express bestrophin 2, a member of the bestrophin family of calcium‐activated chloride channels. This channel was recently proposed to operate as a transduction channel in olfactory sensory cilia. We raised a polyclonal antibody against bestrophin 2 and characterized the expression pattern of this protein in the mouse main olfactory epithelium, septal organ of Masera, and vomeronasal organ. Comparison with the maturation markers growth‐associated protein 43 and olfactory marker protein revealed that bestrophin 2 was expressed in developing sensory neurons of all chemosensory neuroepithelia, but was restricted to proximal cilia in mature sensory neurons. Our results suggest that bestrophin 2 plays a critical role during differentiation and growth of axons and cilia. In mature olfactory receptor neurons, it appears to support growth and function of sensory cilia. J. Comp. Neurol. 515:585–599, 2009. © 2009 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>19480000</pmid><doi>10.1002/cne.22075</doi><tpages>15</tpages></addata></record> |
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| subjects | Animals Axons - physiology Bestrophins calcium activated chloride channels Chloride Channels - genetics Chloride Channels - metabolism Cilia - physiology Eye Proteins - genetics Eye Proteins - metabolism Humans Mice Neurogenesis - physiology neuronal maturation Olfactory Bulb - cytology Olfactory Bulb - metabolism olfactory epithelia Olfactory Marker Protein - genetics Olfactory Marker Protein - metabolism Olfactory Mucosa - cytology Olfactory Mucosa - physiology Olfactory Perception - physiology Olfactory Receptor Neurons - cytology Olfactory Receptor Neurons - metabolism Rats Rats, Wistar Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism regeneration Vomeronasal Organ - cytology Vomeronasal Organ - physiology |
| title | Bestrophin 2: An anion channel associated with neurogenesis in chemosensory systems |
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