Fully Synthetic Vaccines Consisting of Tumor-Associated MUC1 Glycopeptides and a Lipopeptide Ligand of the Toll-like Receptor 2

Fragment condensation of a protected Pam3Cys lipopeptide with unprotected tumor‐associated MUC1 glycopeptides opens the way to vaccine candidates such as A. These vaccines elicit selective immune responses in mice although they lack an immunodominant carrier protein. In principle, such vaccines are...

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Veröffentlicht in:	Angewandte Chemie (International ed.) 2010-05, Vol.49 (21), p.3688-3692
Hauptverfasser:	Kaiser, Anton, Gaidzik, Nikola, Becker, Torsten, Menge, Clara, Groh, Kai, Cai, Hui, Li, Yan-Mei, Gerlitzki, Bastian, Schmitt, Edgar, Kunz, Horst
Format:	Artikel
Sprache:	eng
Schlagworte:	glycopeptides Glycopeptides - chemistry lipopeptides Lipopeptides - chemistry Molecular Structure Mucin-1 - chemistry synthetic vaccines Toll-Like Receptor 2 - chemistry Toll-like receptor 2 tumor-associated antigens Vaccines, Synthetic - chemistry
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Fragment condensation of a protected Pam3Cys lipopeptide with unprotected tumor‐associated MUC1 glycopeptides opens the way to vaccine candidates such as A. These vaccines elicit selective immune responses in mice although they lack an immunodominant carrier protein. In principle, such vaccines are applicable to humans.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201000462