Novel Iodinated Dendritic Nanoparticles for Computed Tomography (CT) Imaging
The design, synthesis, and characterization of novel water-soluble iodinated dendritic nanoparticles, G-4-(DMAA-IPA)37, is reported. They consist of a generation 4 Starburst PAMAM dendrimer core and 3-N-[(N‘,N‘-dimethylaminoacetyl)amino]-α-ethyl-2,4,6-triiodobenzenepropanoic acid (DMAA-IPA) molecule...
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Veröffentlicht in: | Nano letters 2002-06, Vol.2 (6), p.595-599 |
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Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
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Zusammenfassung: | The design, synthesis, and characterization of novel water-soluble iodinated dendritic nanoparticles, G-4-(DMAA-IPA)37, is reported. They consist of a generation 4 Starburst PAMAM dendrimer core and 3-N-[(N‘,N‘-dimethylaminoacetyl)amino]-α-ethyl-2,4,6-triiodobenzenepropanoic acid (DMAA-IPA) molecules covalently attached to the surface. These nanoparticles have an average molecular weight of 37,000 g/mol, a hydrodynamic radius of 2.4 nm and high iodine content (33.06%), while retaining their overall charge and water solubility. Thus, G-4-(DMAA-IPA)37 is the first representative of a novel class of dendritic nanoparticles for computed tomography (CT) imaging. |
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ISSN: | 1530-6984 1530-6992 |
DOI: | 10.1021/nl020246x |