Novel Iodinated Dendritic Nanoparticles for Computed Tomography (CT) Imaging

The design, synthesis, and characterization of novel water-soluble iodinated dendritic nanoparticles, G-4-(DMAA-IPA)37, is reported. They consist of a generation 4 Starburst PAMAM dendrimer core and 3-N-[(N‘,N‘-dimethylaminoacetyl)amino]-α-ethyl-2,4,6-triiodobenzenepropanoic acid (DMAA-IPA) molecule...

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Veröffentlicht in:Nano letters 2002-06, Vol.2 (6), p.595-599
Hauptverfasser: Yordanov, Alexander T, Lodder, Adriana L, Woller, Eric K, Cloninger, Mary J, Patronas, Nicholas, Milenic, Diane, Brechbiel, Martin W
Format: Artikel
Sprache:eng
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Zusammenfassung:The design, synthesis, and characterization of novel water-soluble iodinated dendritic nanoparticles, G-4-(DMAA-IPA)37, is reported. They consist of a generation 4 Starburst PAMAM dendrimer core and 3-N-[(N‘,N‘-dimethylaminoacetyl)amino]-α-ethyl-2,4,6-triiodobenzenepropanoic acid (DMAA-IPA) molecules covalently attached to the surface. These nanoparticles have an average molecular weight of 37,000 g/mol, a hydrodynamic radius of 2.4 nm and high iodine content (33.06%), while retaining their overall charge and water solubility. Thus, G-4-(DMAA-IPA)37 is the first representative of a novel class of dendritic nanoparticles for computed tomography (CT) imaging.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl020246x