Antinociceptive Effects of 14-Membered Cyclopeptide Alkaloids

The analgesic potential of six 14-membered-ring cyclopeptide alkaloids, namely, franganine (1), discarine B (2), scutianines B (3), C (4), and D (5), and adouetine X (6), have been investigated. Among the compounds tested, only franganine (1) and adouetine X (6) produced antinociceptive effects in a...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2009-04, Vol.72 (4), p.608-612
Hauptverfasser:	Trevisan, Gabriela, Maldaner, Graciela, Velloso, Nádia Aléssio, Sant’Anna, Gabriela da Silva, Ilha, Vinicius, Velho Gewehr, Camila de Campos, Rubin, Maribel Antonello, Morel, Ademir Farias, Ferreira, Juliano
Format:	Artikel
Sprache:	eng
Schlagworte:	acute pain adenosinetriphosphatase alkaloids Alkaloids - chemistry Alkaloids - pharmacology analgesic effect Analgesics Analgesics - chemistry Analgesics - isolation & purification Analgesics - pharmacology animal models Animals Biological and medical sciences Calcium-Transporting ATPases - antagonists & inhibitors chemical structure chronic pain cyclic peptides Disease Models, Animal enzyme activity General pharmacology Male mechanism of action Medical sciences Mice Molecular Structure Neuropharmacology nonfood plant products pain Peptides, Cyclic - chemistry Peptides, Cyclic - isolation & purification Peptides, Cyclic - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry Rhamnaceae - chemistry Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors Sterculiaceae - chemistry
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Zusammenfassung:	The analgesic potential of six 14-membered-ring cyclopeptide alkaloids, namely, franganine (1), discarine B (2), scutianines B (3), C (4), and D (5), and adouetine X (6), have been investigated. Among the compounds tested, only franganine (1) and adouetine X (6) produced antinociceptive effects in a mouse model of acute pain, without inducing undesirable side effects. Furthermore, compound 6 also exhibited a pronounced analgesic effect in a chronic neuropathic pain model in mice. It has been found that adouetine X (6) can decrease the activities of Ca2+-ATPase and Na+/K+-ATPase in vitro. Thus, the present findings have demonstrated that adouetine X (6) is a promising analgesic agent.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np800377y