Single-Step DNA Immobilization on Antifouling Self-Assembled Monolayers Covalently Bound to Silicon (111)
Hydrosilylation of alkenes with epoxide-terminated tri(ethylene oxide) moieties on Si−H surfaces yields homogeneous monolayers for the efficient coupling of biomolecules. The wetting properties of the epoxide-functionalized surface allow for the spotting of solutions of biomolecules, making the surf...
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| Veröffentlicht in: | Langmuir 2006-04, Vol.22 (8), p.3494-3496 |
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| container_title | Langmuir |
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| creator | Böcking, Till Kilian, Kristopher A Gaus, Katharina Gooding, J. Justin |
| description | Hydrosilylation of alkenes with epoxide-terminated tri(ethylene oxide) moieties on Si−H surfaces yields homogeneous monolayers for the efficient coupling of biomolecules. The wetting properties of the epoxide-functionalized surface allow for the spotting of solutions of biomolecules, making the surface amenable to microarraying. Immobilization of thiolated DNA was achieved in a single step to fabricate biorecognition interfaces showing the hybridization of complementary DNA at low concentrations and negligible binding of noncomplementary DNA. |
| doi_str_mv | 10.1021/la060331a |
| format | Article |
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Immobilization of thiolated DNA was achieved in a single step to fabricate biorecognition interfaces showing the hybridization of complementary DNA at low concentrations and negligible binding of noncomplementary DNA.</description><subject>Alkenes - chemistry</subject><subject>Base Sequence</subject><subject>Chemistry</subject><subject>DNA - chemistry</subject><subject>Epoxy Compounds - chemistry</subject><subject>Exact sciences and technology</subject><subject>General and physical chemistry</subject><subject>Hydrogen - chemistry</subject><subject>Hydrogen-Ion Concentration</subject><subject>Models, Chemical</subject><subject>Molecular Sequence Data</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Oxides - chemistry</subject><subject>Semiconductors</subject><subject>Silanes - chemistry</subject><subject>Silicon - chemistry</subject><subject>Sulfhydryl Compounds - chemistry</subject><subject>Surface Properties</subject><issn>0743-7463</issn><issn>1520-5827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90U1v1DAQBmALUdFt4cAfQLnQ0kNgHNtxclwWWArlQ6ScLcexkYtjL3ZSsfx6XO2qe0FII81hHr0azSD0FMNLDBV-5STUQAiWD9ACswpK1lT8IVoAp6TktCbH6CSlGwBoCW0foWNcs4ZWuF0g21n_w-mym_SmePN5WVyOY-its3_kZIMvci39ZE2YXYZFp50plynpsXd6KD4FH5zc6piKVbiVTvvJbYvXYfZDMYWiyzkqJ7zAGF88RkdGuqSf7Psp-v7u7fXqfXn1ZX25Wl6VkvJ2Kg2hWFV8kLipDGF00IoNPejeMFIrwLxuWU8px7JRAFyBZi1UA2VAuWlaQ07R-S53E8OvWadJjDYp7Zz0OsxJcEYZvassz_4ra94QIBVkeLGDKoaUojZiE-0o41ZgEHcfEPcfyPbZPnTuRz0c5P7kGTzfA5mUdCZKr2w6OM6hZcCzK3fOpkn_vp_L-DMvRjgT11878YGuv63g41rwQ65USdyEOfp85X8s-Bc9Kqbt</recordid><startdate>20060411</startdate><enddate>20060411</enddate><creator>Böcking, Till</creator><creator>Kilian, Kristopher A</creator><creator>Gaus, Katharina</creator><creator>Gooding, J. 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| fulltext | fulltext |
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| ispartof | Langmuir, 2006-04, Vol.22 (8), p.3494-3496 |
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| language | eng |
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| source | ACS Publications; MEDLINE |
| subjects | Alkenes - chemistry Base Sequence Chemistry DNA - chemistry Epoxy Compounds - chemistry Exact sciences and technology General and physical chemistry Hydrogen - chemistry Hydrogen-Ion Concentration Models, Chemical Molecular Sequence Data Oligonucleotide Array Sequence Analysis Oxides - chemistry Semiconductors Silanes - chemistry Silicon - chemistry Sulfhydryl Compounds - chemistry Surface Properties |
| title | Single-Step DNA Immobilization on Antifouling Self-Assembled Monolayers Covalently Bound to Silicon (111) |
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