Discordance Between Cerebral Spinal Fluid and Plasma HIV Replication in Patients with Neurological Symptoms Who Are Receiving Suppressive Antiretroviral Therapy

Objective. We report data on 11 patients with neurological symptoms and human immunodeficiency virus (HIV) cerebrospinal fluid (CSF) viremia contrasting with suppressed plasma HIV RNA during receipt of combined antiretroviral therapy. Design. We retrospectively identified instances of central nervou...

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Veröffentlicht in:Clinical infectious diseases 2010-03, Vol.50 (5), p.773-778
Hauptverfasser: Canestri, Ana, Lescure, Franæois-Xavier, Jaureguiberry, Stephane, Moulignier, Antoine, Amiel, Corinne, Marcelin, AnneGeneviève, Peytavin, Gilles, Tubiana, Roland, Pialoux, Gilles, Katlama, Christine
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Sprache:eng
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Zusammenfassung:Objective. We report data on 11 patients with neurological symptoms and human immunodeficiency virus (HIV) cerebrospinal fluid (CSF) viremia contrasting with suppressed plasma HIV RNA during receipt of combined antiretroviral therapy. Design. We retrospectively identified instances of central nervous system (CNS) symptoms in patients who had been receiving stable combination antiretroviral therapy. Discordance between plasma and CSF HIV RNA levels was defined by any detectable CSF HIV RNA level >200 copies/mL while plasma levels were
ISSN:1058-4838
1537-6591
DOI:10.1086/650538