Randomized, Controlled Clinical Trial of Zinc Supplementation to Prevent Immunological Failure in HIV-Infected Adults

Background. Adequate zinc is critical for immune function; however, zinc deficiency occurs in 150% of human immunodeficiency virus (HIV)-infected adults. We examined the safety and efficacy of long-term zinc supplementation in relation to HIV disease progression. Methods. A prospective, randomized,...

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Veröffentlicht in:	Clinical infectious diseases 2010-06, Vol.50 (12), p.1653-1660
Hauptverfasser:	Baum, Marianna K., Lai, Shenghan, Sales, Sabrina, Page, J. Bryan, Campa, Adriana
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adults AIDS Arts Biological and medical sciences CD4 Lymphocyte Count Clinical medicine Diarrhea Dietary Supplements Disease Progression Female HIV HIV Infections - drug therapy HIV Infections - immunology HIV Infections - mortality HIV/AIDS Human immunodeficiency virus Human viral diseases Humans Immune System Diseases - prevention & control Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunology Immunopathology Infectious diseases Male Medical research Medical sciences Middle Aged Morbidity Mortality Placebos Treatment Outcome Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load Zinc Zinc - deficiency Zinc - therapeutic use
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Zusammenfassung:	Background. Adequate zinc is critical for immune function; however, zinc deficiency occurs in 150% of human immunodeficiency virus (HIV)-infected adults. We examined the safety and efficacy of long-term zinc supplementation in relation to HIV disease progression. Methods. A prospective, randomized, controlled clinical trial was conducted involving 231 HIV-infected adults with low plasma zinc levels (
ISSN:	1058-4838 1537-6591
DOI:	10.1086/652864