RNA-binding proteins come out of the shadows

Notch1 has an indispensable role in T cell development and NOTCH1 acts as a potent oncogene in T cell leukemia. New data now reveal the role of RNA-binding proteins in regulating the stability of Notch1 mRNA and the induction of T cell leukemia.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature immunology 2010-08, Vol.11 (8), p.697-698
Hauptverfasser:	Nedjic, Jelena, Aifantis, Iannis
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/554 631/250/2502 631/92/612/1230 692/420/755 Animals Biomedical and Life Sciences Biomedicine Humans Immunology Infectious Diseases Mice Mice, Knockout news-and-views Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology Receptor, Notch1 - genetics Receptor, Notch1 - immunology Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology RNA-Binding Proteins - genetics RNA-Binding Proteins - immunology T-Lymphocytes - immunology
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Beschreibung
Zusammenfassung:	Notch1 has an indispensable role in T cell development and NOTCH1 acts as a potent oncogene in T cell leukemia. New data now reveal the role of RNA-binding proteins in regulating the stability of Notch1 mRNA and the induction of T cell leukemia.
ISSN:	1529-2908 1529-2916
DOI:	10.1038/ni0810-697