Effect of a tissue oxygenator (almitrine + raubasine) on the metabolism of 2,3-diphosphoglycerate of rabbits submitted by hypoxia

In normoxic rabbits, the intravenous injection (1 mg/kg) of the product (almitrine + raubasine) do not modify the erythrocytic level of 2,3-DPG. But, after hypoxia (the rabbits being submitted to an oxygen pressure of 7,8 kPa during 20 minutes) the same dose of this product induce a durable rise of...

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Veröffentlicht in:	Comptes rendus des seances de la Societe de biologie et de ses filiales 1980, Vol.174 (6), p.1006-1009
Hauptverfasser:	Callis, A, Dorance, M, Magnan de Bornier, B
Format:	Artikel
Sprache:	fre
Schlagworte:	Almitrine Animals Diphosphoglyceric Acids - blood Erythrocytes - drug effects Erythrocytes - metabolism Hypoxia - blood Kinetics Oxygen - blood Partial Pressure Piperazines - pharmacology Rabbits Secologanin Tryptamine Alkaloids Triazines - pharmacology Yohimbine - pharmacology
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Zusammenfassung:	In normoxic rabbits, the intravenous injection (1 mg/kg) of the product (almitrine + raubasine) do not modify the erythrocytic level of 2,3-DPG. But, after hypoxia (the rabbits being submitted to an oxygen pressure of 7,8 kPa during 20 minutes) the same dose of this product induce a durable rise of erythrocytic 2,3-DPG level which remain, 24 hours latter, + 15% above normal.
ISSN:	0037-9026