Accumulation of 5 alpha-dihydrotestosterone in purified plasma membranes and in the myelin of male rat hypothalamus

The lack of 5 alpha-reductase activity in purified membranes of hypothalamic cells or in myelin was demonstrated. On the other hand, it was shown that incubation of hypothalamic slices with tritiated testosterone resulted in the accumulation and retention of 5 alpha-dihydrotestosterone in purified p...

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Veröffentlicht in:	Comptes rendus des seances de la Societe de biologie et de ses filiales 1980, Vol.174 (6), p.963-968
Hauptverfasser:	Hannouche, N, Samperez, S, Jouan, P
Format:	Artikel
Sprache:	fre
Schlagworte:	Androgens - metabolism Animals Cell Membrane - metabolism Dihydrotestosterone - metabolism Hypothalamus - metabolism In Vitro Techniques Kinetics Male Myelin Sheath - metabolism Rats Testosterone - metabolism Tritium
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Beschreibung
Zusammenfassung:	The lack of 5 alpha-reductase activity in purified membranes of hypothalamic cells or in myelin was demonstrated. On the other hand, it was shown that incubation of hypothalamic slices with tritiated testosterone resulted in the accumulation and retention of 5 alpha-dihydrotestosterone in purified plasmic membranes and in myelin. The biological significance of such a retention remains unknown.
ISSN:	0037-9026