Serial Observations of Circulating Immune Complexes in Patients with Acute Schistosomiasis

Serial Observations of Circulating Immune Complexes in Patients with Acute Schistosomiasis

To define further the role of circulating immune complexes in acute schistosomiasis, serial determinations of [125I]C1q binding activity (C1qBA) in 15 patients with this disease were made before and after treatment with niridazole. Levels of C1qBA were elevated in 13 of these patients and in general...

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Veröffentlicht in:The Journal of infectious diseases 1980-11, Vol.142 (5), p.665-670
Hauptverfasser: Hiatt, Robert A., Ottesen, Eric A., Sotomayor, Z. Roberto, Lawley, Thomas J.
Format: Artikel
Sprache:eng
Schlagworte:
Acute Disease
Adolescent
Adult
Antigen antibody complex
Antigen-Antibody Complex - analysis
Antigens
Child
Complement C1
Eggs
Eosinophils
Female
Humans
Immune complex diseases
Immunoglobulin G - analysis
Immunoglobulin M - analysis
Infections
Male
Parasite Egg Count
Parasitic diseases
Pathogenesis
Schistosoma mansoni
Schistosomiasis
Schistosomiasis - immunology
Severity of illness indices
Time Factors
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Zusammenfassung:To define further the role of circulating immune complexes in acute schistosomiasis, serial determinations of [125I]C1q binding activity (C1qBA) in 15 patients with this disease were made before and after treatment with niridazole. Levels of C1qBA were elevated in 13 of these patients and in general rose early in the course of disease, reaching maximal levels by 10 weeks after exposure; the levels were correlated with disease severity (r = 0.70, P
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/142.5.665