Effect of 1,25-dihydroxycholecalciferol and 1,25-dihydroxycholecalciferol glycoside on 2,3-diphosphoglycerate levels of the rat erythrocyte

The erythrocytes of rats treated with 1, 25-dihydroxycholecalciferol or 1, 25-dihydroxycholecalciferol glycoside showed decreased levels of 2, 3-diphosphoglycerate. The same result has been obtained in vitro, indicating a direct effect of the sterol on the red cell. The glycoside is less active than...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pflügers Archiv 1980-12, Vol.389 (1), p.81-83
Hauptverfasser:	Skliar, M I, Fernandez, M C, Faienza, H, Orsatti, M B, Puche, R C, Boland, R L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcitriol Dihydroxycholecalciferols - pharmacology Diphosphoglyceric Acids - metabolism Erythrocytes - metabolism Erythropoietin - blood Female Hydroxycholecalciferols - pharmacology Hypoxia - blood Hypoxia - metabolism Lactates - blood Male Oxygen - blood Pyruvates - blood Rats
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The erythrocytes of rats treated with 1, 25-dihydroxycholecalciferol or 1, 25-dihydroxycholecalciferol glycoside showed decreased levels of 2, 3-diphosphoglycerate. The same result has been obtained in vitro, indicating a direct effect of the sterol on the red cell. The glycoside is less active than the free sterol in vivo and more active in vitro. The decreased levels of diphosphoglycerate induced tissue hypoxia as shown by a higher plasma lactate/pyruvate ratio and a three fold increase in plasma erythropoietin concentration.
ISSN:	0031-6768 1432-2013
DOI:	10.1007/BF00587932