Anticoccidials. V. Synthesis and Anticoccidial Activity of 2(1H)-Pyrazinone 4-Oxide Derivatives

A series of 1-, 3-, 5- and 6-substituted 2(1H)-pyrazinone 4-oxides were synthesized and tested for anticoccidial activity. Of the compounds tested, 1-(β-D-ribofuranosyl)-(22), 1-(2, 3, 5-tri-O-benzoyl-β-D-ribofuranosyl)-(21) and 1-(2, 3, 5-tri-O-acetyl-β-D-ribofuranosyl)-2(1H)-pyrazinone 4-oxides (2...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1980/09/25, Vol.28(9), pp.2734-2747
Hauptverfasser: MANO, MITSUHIKO, SEO, TAKUJI, HATTORI, TOSHINORI, KANEKO, TATSUHIKO, IMAI, KINICHI
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Sprache:eng
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Zusammenfassung:A series of 1-, 3-, 5- and 6-substituted 2(1H)-pyrazinone 4-oxides were synthesized and tested for anticoccidial activity. Of the compounds tested, 1-(β-D-ribofuranosyl)-(22), 1-(2, 3, 5-tri-O-benzoyl-β-D-ribofuranosyl)-(21) and 1-(2, 3, 5-tri-O-acetyl-β-D-ribofuranosyl)-2(1H)-pyrazinone 4-oxides (24) showed high activity.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.28.2734